{"id":"W4362471113","doi":"10.3390/curroncol30040302","title":"Consensus Recommendations to Optimize the Detection and Reporting of NTRK Gene Fusions by RNA-Based Next-Generation Sequencing","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; William Osler Health System; Centre Hospitalier de l’Université de Montréal; Manitoba Health; Hôpital Maisonneuve-Rosemont; University of Alberta; Nova Scotia Health Authority; Jewish General Hospital; Sunnybrook Health Science Centre; McMaster University; University Health Network; Ottawa Hospital; Health Sciences Centre; McGill University Health Centre; Kingston Health Sciences Centre; Queen's University; Institut universitaire de cardiologie et de pneumologie de Québec; Hospital for Sick Children; University of Saskatchewan; Princess Margaret Cancer Centre; Hamilton Health Sciences; University of Toronto","funders":"Bayer Canada","keywords":"Fusion gene; Medicine; RNA; Computational biology; DNA sequencing; Gene; Gene nomenclature; Bioinformatics; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.02861854,0.001715695,0.003257465,0.005749753,0.0008347338,0.003006786,0.007413574,0.008347268,0.01148102],"category_scores_gemma":[0.03454736,0.001074438,0.00409218,0.004577226,0.001407454,0.004168458,0.002982582,0.008086732,0.01072644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004518044,"about_ca_system_score_gemma":0.02083471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008091422,"about_ca_topic_score_gemma":0.009853479,"domain_scores_codex":[0.989176,0.003845292,0.00244204,0.0006312153,0.003184591,0.0007209008],"domain_scores_gemma":[0.9604808,0.01193785,0.004110004,0.0007462211,0.02043919,0.002285913],"domain_codex":null,"domain_gemma":"reporting","domain_candidate":"reporting","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000868341,0.0001420259,0.0002351938,0.03109673,0.0001665845,0.0003656693,0.0002309562,0.0005160945,0.0007589278,0.006717661,0.4468531,0.5128302],"study_design_scores_gemma":[0.00005401102,0.00004222508,0.0003686431,0.03001702,0.0001974921,0.0003256859,0.0001429846,0.00007852145,0.0002388851,0.003521321,0.9649779,0.00003521341],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003198536,0.8115892,0.007205935,0.1478235,0.01397733,0.00123625,0.001898862,0.00039221,0.01555692],"genre_scores_gemma":[0.001687813,0.9136178,0.02551506,0.04061222,0.002337971,0.001856574,0.00309348,0.00008177706,0.01119718],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9713814,"threshold_uncertainty_score":0.1513512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3639750626018639,"score_gpt":0.4444571416467175,"score_spread":0.08048207904485355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}