{"id":"W4362471442","doi":"10.1038/s41419-023-05725-z","title":"USP18 is an essential regulator of muscle cell differentiation and maturation","year":2023,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Engineering and Physical Sciences Research Council; Chinese Academy of Medical Sciences; AFM-Téléthon; Pfizer","keywords":"ISG15; Biology; Transcriptome; Myogenesis; Cell biology; Cellular differentiation; Regulator; Gene expression; Myocyte; Regulation of gene expression; Gene; Ubiquitin; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001850491,0.0004887143,0.0003543676,0.0004227399,0.0002762967,0.0003856906,0.0002143246,0.0002465281,0.001095695],"category_scores_gemma":[0.0001319346,0.0001910584,0.0003148942,0.0002155748,0.0002178516,0.0001932167,0.0004220037,0.0003064192,0.0007038108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003309122,"about_ca_system_score_gemma":0.0002306509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003222389,"about_ca_topic_score_gemma":0.0003130146,"domain_scores_codex":[0.9997962,0.00002015309,0.00002647607,0.00006132696,0.00006447724,0.00003144108],"domain_scores_gemma":[0.999804,0.00001314808,0.00008616308,0.00001851371,0.00003341885,0.00004479825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001100554,0.00001226811,0.001318051,0.00008643538,0.00001157969,0.0002230266,0.00001737532,0.00004436241,0.9918556,0.0003411536,0.0002622285,0.005717881],"study_design_scores_gemma":[0.00002052892,0.0001859237,0.02996346,0.00002591837,0.00004039631,0.001580825,0.00003311445,0.001132072,0.9380108,0.0003161484,0.02868018,0.00001059116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947422,0.0223009,0.02003889,0.0003468739,0.0001501332,0.00008958331,0.00370212,0.000749502,0.005200018],"genre_scores_gemma":[0.9771588,0.005185062,0.006490117,0.00007688854,0.00004379598,0.00005378882,0.003521576,0.0000784618,0.007391504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001095695,"threshold_uncertainty_score":0.003665447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01035911795247767,"score_gpt":0.2267825730139029,"score_spread":0.2164234550614252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}