{"id":"W4362472971","doi":"10.3233/jnd-221656","title":"Efficacy and Safety of Viltolarsen in Boys With Duchenne Muscular Dystrophy: Results From the Phase 2, Open-Label, 4-Year Extension Study","year":2023,"lang":"en","type":"article","venue":"Journal of Neuromuscular Diseases","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Duchenne muscular dystrophy; Medicine; Extension (predicate logic); Open label; Pediatrics; Muscular dystrophy; Physical medicine and rehabilitation; Internal medicine; Adverse effect; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002529045,0.001046414,0.001512799,0.0003205613,0.0003041948,0.000535449,0.0007344525,0.001192401,0.002516062],"category_scores_gemma":[0.001490633,0.000337753,0.001195366,0.0001879337,0.0004859408,0.0006993878,0.0003122807,0.001669266,0.0004025432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005458936,"about_ca_system_score_gemma":0.0007344826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007156627,"about_ca_topic_score_gemma":0.001706232,"domain_scores_codex":[0.9991892,0.0004618232,0.00005357973,0.0001072511,0.00008807172,0.0001001043],"domain_scores_gemma":[0.9985252,0.0003650182,0.0004498536,0.0001098013,0.000152147,0.0003980263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7656233,0.07969228,0.01408588,0.001170541,0.001364514,0.000265458,0.0005282614,0.001334879,0.04376362,0.00009023104,0.001447763,0.09063335],"study_design_scores_gemma":[0.2266912,0.7315032,0.03645701,0.0000548401,0.0004779153,0.000190399,0.00009432847,0.0004938519,0.002990681,0.00004134392,0.0009792795,0.00002593323],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975941,0.000871274,0.0001770453,0.00006624501,0.00002557,0.0004726214,0.0004635196,0.00003319269,0.0002964991],"genre_scores_gemma":[0.9952899,0.0006181754,0.0008481678,0.0002261305,0.00007169233,0.0009012908,0.001009508,0.00001326366,0.001021924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002529045,"threshold_uncertainty_score":0.01337498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02463554136164334,"score_gpt":0.3033043974907585,"score_spread":0.2786688561291152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}