{"id":"W4362473129","doi":"10.1016/j.jbiotec.2023.03.011","title":"In-situ synchrotron imaging, experimental, and computational investigations on the efficiency of Trametes versicolor laccase on detoxification of P-Cresyl Sulfate (PCS) Protein Bound Uremic Toxin (PBUT)","year":2023,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of Saskatchewan","funders":"","keywords":"Trametes versicolor; Laccase; Chemistry; Detoxification (alternative medicine); Docking (animal); Chromatography; Biochemistry; Enzyme; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002073002,0.000236453,0.0003009321,0.0001533935,0.0003039107,0.0003029367,0.0006295129,0.0003935225,0.001635387],"category_scores_gemma":[0.0002603974,0.0001984877,0.0003453729,0.0003428171,0.0002622428,0.0003363087,0.0001538431,0.0003512591,0.00009166158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000440875,"about_ca_system_score_gemma":0.0002872257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002560844,"about_ca_topic_score_gemma":0.002906377,"domain_scores_codex":[0.9999388,0.000008426653,0.000003004501,0.00001292706,0.00001969294,0.00001710051],"domain_scores_gemma":[0.999854,0.00006710166,0.00002136029,0.00001667727,0.00003252889,0.000008298399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006996932,0.0007543675,0.01233627,0.0005065101,0.000103487,0.0004185095,0.0003289703,0.2289205,0.7413111,0.002628793,0.001112375,0.01087939],"study_design_scores_gemma":[0.00003612609,0.0001817488,0.0112602,0.000004919874,0.00003566716,0.00006597765,0.0001701725,0.7705673,0.2167941,0.0003572121,0.0005065268,0.0000200627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968113,0.00006563503,0.001940401,0.00007340987,0.000004126111,0.000003183031,0.0001325438,0.0000577243,0.0009114876],"genre_scores_gemma":[0.9978941,0.00006261847,0.001574268,0.000008764569,0.000001545559,0.00000507178,0.0001430182,0.0000102563,0.0003003117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002560844,"threshold_uncertainty_score":0.005470872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01364338792494825,"score_gpt":0.2747706805016373,"score_spread":0.261127292576689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}