{"id":"W4362473129","doi":"10.1016/j.jbiotec.2023.03.011","title":"In-situ synchrotron imaging, experimental, and computational investigations on the efficiency of Trametes versicolor laccase on detoxification of P-Cresyl Sulfate (PCS) Protein Bound Uremic Toxin (PBUT)","year":2023,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of Saskatchewan","funders":"","keywords":"Trametes versicolor; Laccase; Chemistry; Detoxification (alternative medicine); Docking (animal); Chromatography; Biochemistry; Enzyme; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002485604,0.00008367957,0.0001612932,0.0002778177,0.00006527771,0.000008203992,0.0001467752,0.0000964697,0.000006289324],"category_scores_gemma":[0.0002735571,0.00006321201,0.00006457025,0.0003482367,0.000327636,0.000008642559,0.00005113898,0.0001589408,0.000002093994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002972559,"about_ca_system_score_gemma":0.00005105053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001399052,"about_ca_topic_score_gemma":0.000007971712,"domain_scores_codex":[0.9992301,0.00005426927,0.0003432339,0.0001349031,0.0001327679,0.0001047156],"domain_scores_gemma":[0.9993231,0.00005214336,0.0003685324,0.0001378626,0.00009766621,0.0000207453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001135304,0.0001099908,0.0002514564,0.000008347977,0.00004998264,0.000003792717,0.00008348515,0.0003467595,0.9972354,0.0009384205,0.0005078688,0.0003510297],"study_design_scores_gemma":[0.0003657308,0.000656259,0.0009521021,0.00006011456,0.00001463034,0.00001439955,0.0007942615,0.0005527243,0.9958296,0.0004276303,0.0002782886,0.00005426112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941749,0.000414541,0.0003868898,0.004783818,0.00004115693,0.0001643346,0.000006204418,0.000004084142,0.00002407505],"genre_scores_gemma":[0.9993796,0.0001239641,0.0003289903,0.000109044,0.00002159108,0.0000125361,0.000004813478,0.000005330096,0.00001408932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005204745,"threshold_uncertainty_score":0.2577711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01364338792494825,"score_gpt":0.2747706805016373,"score_spread":0.261127292576689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}