{"id":"W4362478996","doi":"10.1158/1535-7163.c.6535384","title":"Data from Digitoxin-Induced Cytotoxicity in Cancer Cells Is Mediated through Distinct Kinase and Interferon Signaling Networks","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Digitoxin; Kinase; Signal transduction; Pharmacology; Cancer research; Chemistry; Biology; Biochemistry; Internal medicine; Heart failure; Medicine; Digoxin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001379179,0.000339131,0.0003153524,0.0004579908,0.000352553,0.0003489607,0.0001572006,0.0003298278,0.005191055],"category_scores_gemma":[0.0001670562,0.0001160323,0.0005676307,0.0006617599,0.0001540731,0.0002347807,0.0002006333,0.0006447755,0.001183137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000401948,"about_ca_system_score_gemma":0.0002595237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007410435,"about_ca_topic_score_gemma":0.001166571,"domain_scores_codex":[0.9997733,0.00001828525,0.00002825012,0.00004749259,0.00009913327,0.00003344429],"domain_scores_gemma":[0.9998884,0.00002484091,0.00002645862,0.00001696308,0.00002735853,0.00001586598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007319776,0.00007218822,0.002188213,0.0002954702,0.00003907383,0.0001212285,0.00003807416,0.0002427743,0.9876216,0.0001993892,0.0005760451,0.007874034],"study_design_scores_gemma":[0.00004556146,0.0003752961,0.05506155,0.00001740647,0.00006006015,0.0005611097,0.0000935782,0.001762608,0.93476,0.000139488,0.007110484,0.00001289724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9606247,0.008099007,0.007266521,0.0008498171,0.0001956984,0.0001139342,0.01218876,0.0004497722,0.01021175],"genre_scores_gemma":[0.9685159,0.004728355,0.005216799,0.0005239783,0.00003018987,0.000188986,0.01329188,0.00003652455,0.007467445],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.005191055,"threshold_uncertainty_score":0.01736581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.080946247565349,"score_gpt":0.3115280072859788,"score_spread":0.2305817597206298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}