{"id":"W4362479416","doi":"10.1158/1535-7163.c.6535299.v1","title":"Data from Transcription Factor Stat5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression <i>In vivo</i>","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Gene knockdown; LNCaP; Transactivation; Cancer research; Androgen receptor; Prostate cancer; Androgen deprivation therapy; STAT5; MG132; Biology; Transcription factor; Chemistry; Apoptosis; Medicine; Internal medicine; Signal transduction; Proteasome inhibitor; Cell biology; Cancer; Proteasome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002451008,0.000833894,0.0005344067,0.0007108218,0.0003408424,0.0003983152,0.0003016813,0.0004906027,0.01281329],"category_scores_gemma":[0.00010366,0.0002852671,0.000858685,0.000539091,0.0003689015,0.0003188538,0.0001700575,0.001902033,0.002496327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006035894,"about_ca_system_score_gemma":0.0005620091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002737961,"about_ca_topic_score_gemma":0.00475314,"domain_scores_codex":[0.999602,0.00003751912,0.0000473567,0.00008213847,0.0001572603,0.00007372964],"domain_scores_gemma":[0.9998168,0.00002608595,0.00002996839,0.00001912231,0.000025562,0.00008254433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001150269,0.000358258,0.0003439385,0.0003578302,0.000051207,0.00009066851,0.00004885922,0.0002167586,0.9898,0.000373719,0.002504455,0.004704123],"study_design_scores_gemma":[0.0001617906,0.001461035,0.01122795,0.00002566837,0.00008095516,0.0003576538,0.0000951744,0.001461329,0.969905,0.0001070307,0.01509722,0.00001932374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.8956402,0.01066373,0.01181447,0.002047973,0.001038302,0.0003059553,0.05213292,0.002032791,0.0243237],"genre_scores_gemma":[0.891459,0.005787793,0.01015399,0.0009127968,0.00009078647,0.000591298,0.03211129,0.0002501181,0.05864297],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.01281329,"threshold_uncertainty_score":0.04286474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0884125551900787,"score_gpt":0.3644037347172555,"score_spread":0.2759911795271768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}