{"id":"W4362479791","doi":"10.1158/1535-7163.c.6535437","title":"Data from The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes &lt;i&gt;MYCN&lt;/i&gt;-Amplified Neuroblastoma &lt;i&gt;In Vivo&lt;/i&gt;","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Neuroblastoma; Aurora kinase; Aurora inhibitor; Kinase; Aurora B kinase; Molecular biology; Cancer research; Biology; Mitosis; Aurora A kinase; Chemistry; Apoptosis; Cell cycle; Cell biology; Cytokinesis; Cell culture; Cell; Biochemistry; Cell division; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011982,0.0006185725,0.0005713179,0.0003436235,0.0001959735,0.0002665851,0.000324942,0.000346492,0.01123673],"category_scores_gemma":[0.00009658133,0.0001639683,0.0004439485,0.0003251146,0.0001888455,0.0002619694,0.0001486429,0.00120644,0.001877852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005776151,"about_ca_system_score_gemma":0.0006547824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002943018,"about_ca_topic_score_gemma":0.005124463,"domain_scores_codex":[0.9998067,0.00001369054,0.00001928982,0.00002900549,0.00008708566,0.00004416562],"domain_scores_gemma":[0.9999045,0.00001145305,0.00001771313,0.0000113088,0.00001825539,0.0000367448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001936915,0.000397625,0.0003496558,0.0002679396,0.00004110472,0.0001393881,0.00002170057,0.0002496024,0.9799353,0.0003260341,0.00261016,0.01372452],"study_design_scores_gemma":[0.0002574338,0.002258495,0.006324698,0.0000142721,0.0000643482,0.0004059104,0.00002933347,0.0007311486,0.9741554,0.00007463965,0.01567066,0.00001362625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9127561,0.00812788,0.006909729,0.001040399,0.0005765539,0.0003183192,0.03356892,0.001380422,0.03532154],"genre_scores_gemma":[0.9257234,0.004508675,0.003353913,0.0004817661,0.0000495719,0.0003106362,0.03378734,0.0001203023,0.03166439],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.01123673,"threshold_uncertainty_score":0.03759062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02224866241257982,"score_gpt":0.2488485192917793,"score_spread":0.2265998568791995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}