{"id":"W4362486236","doi":"10.1158/1535-7163.c.6543604","title":"Data from Inhibition of the MNK1/2–eIF4E Axis Augments Palbociclib-Mediated Antitumor Activity in Melanoma and Breast Cancer","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of Toronto; University Health Network; Jewish General Hospital; McGill University; Princess Margaret Cancer Centre; University of Manitoba; Hôpital Maisonneuve-Rosemont; Telesta Therapeutics (Canada)","funders":"","keywords":"Palbociclib; Cancer research; EIF4E; Clonogenic assay; Melanoma; Downregulation and upregulation; Cell cycle; Cancer; Survivin; Medicine; Breast cancer; Pharmacology; Biology; Cell; Translation (biology); Internal medicine; Messenger RNA; Biochemistry; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001877219,0.0005440864,0.000500978,0.0005347836,0.0002424211,0.000360155,0.0002567889,0.0003561937,0.005502366],"category_scores_gemma":[0.0001314479,0.0001798237,0.0005325685,0.0003092637,0.0001519509,0.0001896008,0.0001562963,0.001230831,0.00100658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004859364,"about_ca_system_score_gemma":0.0004383524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001087225,"about_ca_topic_score_gemma":0.002876174,"domain_scores_codex":[0.9998067,0.00001996895,0.00001989368,0.00002780223,0.00007339414,0.00005225845],"domain_scores_gemma":[0.9999208,0.00001107325,0.00001303746,0.000009081388,0.00001645018,0.00002958941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002722207,0.00074934,0.0008388375,0.0003974667,0.00006899529,0.000117208,0.00002330069,0.0003290655,0.9799843,0.000218454,0.001546406,0.01300433],"study_design_scores_gemma":[0.0005871355,0.003516491,0.03722678,0.00003426045,0.0001205144,0.0006138457,0.00007725486,0.001921837,0.9336312,0.0001335924,0.0221171,0.00002003112],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9645715,0.01072685,0.001988543,0.001234548,0.0003843159,0.0002167448,0.008852923,0.0003903644,0.0116343],"genre_scores_gemma":[0.965458,0.005547609,0.00244434,0.0006344741,0.00005095486,0.0003196342,0.01147047,0.00006540151,0.01400904],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.005502366,"threshold_uncertainty_score":0.01840729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0656322307284416,"score_gpt":0.3365894704818471,"score_spread":0.2709572397534055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}