{"id":"W4362507417","doi":"10.1158/2159-8290.cd-23-0004","title":"A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; McGill Genome Centre; Montreal Children's Hospital; Jewish General Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation Charles-Bruneau; National Cancer Institute; National Institutes of Health; Cancer Research UK; Great Ormond Street Hospital Charity; Brain Research UK; Canadian Institutes of Health Research; Genome Canada","keywords":"Biology; Histone H3; Cancer research; Glioma; Phenotype; Histone; Mutant; Genetic heterogeneity; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005319321,0.0008564758,0.0003917181,0.0008229975,0.0003125696,0.0004541503,0.0005976848,0.0005359662,0.001731394],"category_scores_gemma":[0.0001819704,0.0002404289,0.0005941511,0.000374776,0.0002545226,0.0003471844,0.0003526836,0.001447813,0.0007797416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004644073,"about_ca_system_score_gemma":0.0004796405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008307298,"about_ca_topic_score_gemma":0.001865461,"domain_scores_codex":[0.9996401,0.0000403324,0.00004895711,0.0000600064,0.0001481995,0.00006233885],"domain_scores_gemma":[0.9997452,0.00003415184,0.00005767761,0.00006300234,0.00003793099,0.00006202077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000337346,0.0002677006,0.0007197233,0.0001893808,0.00004411645,0.000260577,0.00006829398,0.0007783771,0.9864232,0.0009496326,0.001450206,0.008511499],"study_design_scores_gemma":[0.00009944736,0.00284033,0.004452527,0.00005856029,0.0001736644,0.00240214,0.00009976815,0.00251803,0.9554299,0.000311251,0.03159197,0.00002249332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9049292,0.007318675,0.05567503,0.0008534777,0.0003842321,0.001428348,0.01599045,0.001329471,0.01209119],"genre_scores_gemma":[0.9001834,0.01203253,0.03877039,0.0004410898,0.0000642231,0.001853913,0.02862995,0.0004252876,0.01759923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001731394,"threshold_uncertainty_score":0.005792081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04374262992398484,"score_gpt":0.282874506056034,"score_spread":0.2391318761320492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}