{"id":"W4362507417","doi":"10.1158/2159-8290.cd-23-0004","title":"A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; McGill Genome Centre; Montreal Children's Hospital; Jewish General Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation Charles-Bruneau; National Cancer Institute; National Institutes of Health; Cancer Research UK; Great Ormond Street Hospital Charity; Brain Research UK; Canadian Institutes of Health Research; Genome Canada","keywords":"Biology; Histone H3; Cancer research; Glioma; Phenotype; Histone; Mutant; Genetic heterogeneity; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141023,0.0002468392,0.0005821798,0.0002912427,0.00008255472,0.00003614323,0.0001299552,0.00009064405,0.0001713205],"category_scores_gemma":[0.000004088809,0.000193695,0.0002074182,0.0006794058,0.00008371416,0.0002536766,0.0000280756,0.0001183794,0.00004089109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001534448,"about_ca_system_score_gemma":0.0001586653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000505031,"about_ca_topic_score_gemma":0.0000478311,"domain_scores_codex":[0.9983592,0.00005600039,0.0003903749,0.0003995545,0.00037892,0.0004159452],"domain_scores_gemma":[0.9990697,0.0001892372,0.0001175207,0.0004438332,0.00006528679,0.0001144451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002565542,0.004350262,0.5909883,0.005876798,0.002543218,0.001556488,0.004435905,0.02048528,0.2837224,0.04500697,0.03438449,0.00408439],"study_design_scores_gemma":[0.01662462,0.001485092,0.6065415,0.001124996,0.003327629,0.0001668841,0.001572332,0.001376906,0.3420856,0.02147209,0.002728213,0.001494096],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97785,0.01926691,0.00008411591,0.0007375961,0.0004957676,0.0005367898,0.0005896863,0.0001011504,0.0003380334],"genre_scores_gemma":[0.9848583,0.01352599,0.00004386788,0.00009818765,0.0003114195,0.0003032962,0.0001447989,0.00004840382,0.0006657221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0583632,"threshold_uncertainty_score":0.7898653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04374262992398484,"score_gpt":0.282874506056034,"score_spread":0.2391318761320492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}