{"id":"W4362508739","doi":"10.1016/j.tcm.2023.03.006","title":"Opioids-induced inhibition of HERG ion channels and sudden cardiac death, a systematic review of current literature","year":2023,"lang":"en","type":"review","venue":"Trends in Cardiovascular Medicine","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"","keywords":"hERG; Medicine; QT interval; Long QT syndrome; Sudden cardiac death; Opioid; Sudden death; Methadone; Adverse effect; Morphine; Pharmacology; Anesthesia; Internal medicine; Cardiology; Potassium channel","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002756953,0.0006963988,0.01328517,0.001324029,0.0000314487,0.00000438469,0.0001247596,0.0005383621,0.00001454661],"category_scores_gemma":[0.0007212814,0.0004705813,0.003843973,0.002413592,0.000154385,0.0000526604,0.0001109901,0.000997048,0.000006678286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001505685,"about_ca_system_score_gemma":0.0001734936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002361651,"about_ca_topic_score_gemma":6.47945e-7,"domain_scores_codex":[0.9946705,0.001268463,0.002005147,0.0007469227,0.0009126848,0.0003962447],"domain_scores_gemma":[0.9971953,0.0003058399,0.0007038427,0.001359588,0.0002738692,0.0001615735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.00001420545,0.00002983315,8.971792e-7,0.8490257,0.003761531,0.0005571552,0.0001636047,4.518044e-7,0.000008720955,0.00006151637,0.0002605554,0.1461158],"study_design_scores_gemma":[0.0008737387,0.0003408596,0.0000175861,0.9583749,0.0269993,0.0009928651,0.00002366578,0.0000011436,0.00001668363,0.00002495469,0.01203661,0.0002977363],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001537801,0.9961005,0.000004359411,0.00005330457,0.001069324,0.00232103,0.00006844682,0.00004875525,0.0001804288],"genre_scores_gemma":[0.0005025521,0.9963847,0.000007902709,0.00002730085,0.001227091,0.0004771613,0.001182007,0.0000911403,0.0001001755],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1458181,"threshold_uncertainty_score":0.9997746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05895455977196985,"score_gpt":0.3590209344178453,"score_spread":0.3000663746458755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}