{"id":"W4362509514","doi":"10.1172/jci168595","title":"Seeking neuroprotection in multiple sclerosis: an ongoing challenge","year":2023,"lang":"en","type":"letter","venue":"Journal of Clinical Investigation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Multiple sclerosis; Neuroprotection; Neuroscience; Medicine; Experimental autoimmune encephalomyelitis; Oligodendrocyte; Inflammation; Disease; Myelin sheath; Demyelinating disease; Demyelinating Disorder; Myelin; Immunology; Bioinformatics; Central nervous system; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00663843,0.0006993452,0.002351618,0.0007783893,0.002867767,0.004215434,0.001924819,0.02121081,0.003816767],"category_scores_gemma":[0.0180634,0.0003977642,0.0008561123,0.0007215422,0.005477926,0.00775415,0.001916108,0.02582611,0.003999454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003032684,"about_ca_system_score_gemma":0.004203413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008285148,"about_ca_topic_score_gemma":0.002120542,"domain_scores_codex":[0.995382,0.001899765,0.0006126749,0.0003170457,0.001535078,0.0002534281],"domain_scores_gemma":[0.9816607,0.01067189,0.0008645828,0.0008127405,0.003710729,0.002279374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001992805,0.0003213595,0.000629003,0.000820172,0.0000437205,0.002836066,0.000446873,0.0001303538,0.001432248,0.01761702,0.8038496,0.1716743],"study_design_scores_gemma":[0.0002155159,0.0002878519,0.0007979486,0.001348801,0.00005027363,0.004149618,0.001380128,0.0003274821,0.000590858,0.04212552,0.948655,0.00007096503],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003782226,0.0247693,0.0002570022,0.9585127,0.01507487,0.000008622598,0.000008064732,0.00002781403,0.0009633788],"genre_scores_gemma":[0.007728946,0.06106373,0.001976068,0.66542,0.2598429,0.00006703933,0.00003131396,0.00003503822,0.003834963],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02121081,"threshold_uncertainty_score":0.03510773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4557205031992891,"score_gpt":0.4301432802239771,"score_spread":0.02557722297531195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}