{"id":"W4362510246","doi":"10.1016/j.jbc.2023.104669","title":"Cyp26a1 supports postnatal retinoic acid homeostasis and glucoregulatory control","year":2023,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Queen's University; National Institutes of Health; Cancer Research Institute","keywords":"Retinoic acid; Endocrinology; Glucose homeostasis; Gene knockdown; Internal medicine; Biology; Homeostasis; Endogeny; Tretinoin; Glycogen; Cell culture; Insulin; Biochemistry; Apoptosis; Insulin resistance; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004578107,0.0001881892,0.0002853512,0.00003075038,0.00007063391,0.00002814925,0.0002510897,0.0003628065,0.00007118202],"category_scores_gemma":[0.0003966659,0.0001377409,0.0001698649,0.0001214255,0.0002483166,0.000006249902,0.000118241,0.0002361063,0.000006165337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001698019,"about_ca_system_score_gemma":0.0001046053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.206631e-7,"about_ca_topic_score_gemma":5.20171e-8,"domain_scores_codex":[0.9988055,0.00004608519,0.0004076926,0.0002687677,0.0001846588,0.0002872954],"domain_scores_gemma":[0.9991508,0.00003546728,0.0002815436,0.0001925291,0.0001541219,0.0001855909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000201698,0.00002864323,0.006251903,0.00005447875,0.00006513923,0.0002011013,0.00001053292,0.000004754089,0.989245,0.000003264858,0.002006446,0.001927051],"study_design_scores_gemma":[0.0008344481,0.0003227153,0.006529057,0.00002084757,0.00002700095,0.001078215,0.0001217358,0.000008951807,0.9825975,0.0001205057,0.008146778,0.0001922954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932231,0.005883892,0.0001001238,0.0001683163,0.0001156283,0.00005031581,0.00003037619,0.00001787356,0.0004103519],"genre_scores_gemma":[0.9965229,0.002326193,0.0001129068,0.0001584591,0.0005699503,0.000003459481,0.00007883381,0.00001474201,0.0002125537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006647537,"threshold_uncertainty_score":0.5616912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009046304726571459,"score_gpt":0.2327222595222919,"score_spread":0.2236759547957205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}