{"id":"W4362510246","doi":"10.1016/j.jbc.2023.104669","title":"Cyp26a1 supports postnatal retinoic acid homeostasis and glucoregulatory control","year":2023,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Queen's University; National Institutes of Health; Cancer Research Institute","keywords":"Retinoic acid; Endocrinology; Glucose homeostasis; Gene knockdown; Internal medicine; Biology; Homeostasis; Endogeny; Tretinoin; Glycogen; Cell culture; Insulin; Biochemistry; Apoptosis; Insulin resistance; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001528021,0.0003692047,0.0002320623,0.0004347788,0.0001903324,0.0003370508,0.0001754507,0.0002035444,0.001718683],"category_scores_gemma":[0.0001533673,0.0001719874,0.0002399226,0.0001442351,0.0003181178,0.0001967656,0.0002404055,0.0005196946,0.0006371861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002812165,"about_ca_system_score_gemma":0.0002254563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006818063,"about_ca_topic_score_gemma":0.001347812,"domain_scores_codex":[0.9998658,0.00001668666,0.00001061873,0.000042238,0.00003801147,0.00002661531],"domain_scores_gemma":[0.9997163,0.00002153387,0.00009073355,0.00003318947,0.00004338088,0.00009485228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001079598,0.000005615979,0.0006141496,0.00002325653,0.000002827133,0.00006516914,0.0000133075,0.00002885632,0.9974291,0.000180282,0.00004140559,0.001488124],"study_design_scores_gemma":[0.00001181257,0.0001438314,0.03331361,0.00001496464,0.00002229178,0.0005210059,0.00004992744,0.0004337612,0.9599239,0.0001351476,0.00542169,0.000008110839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845247,0.003447189,0.006625259,0.0002524272,0.00004092017,0.00002301783,0.001114227,0.0003181902,0.003654014],"genre_scores_gemma":[0.9872466,0.001749319,0.002777206,0.00004485291,0.00002210895,0.00002728552,0.0008892856,0.00009714958,0.007146208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001718683,"threshold_uncertainty_score":0.005749524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009046304726571459,"score_gpt":0.2327222595222919,"score_spread":0.2236759547957205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}