{"id":"W4362521185","doi":"10.1073/pnas.2301081120","title":"<i>Arabidopsis</i> HOT3/eIF5B1 constrains rRNA RNAi by facilitating 18S rRNA maturation","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; University of Massachusetts Amherst; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; National Institutes of Health; National Institute of General Medical Sciences; Chinese Academy of Sciences; China Agricultural University","keywords":"18S ribosomal RNA; Biology; Ribosomal RNA; Eukaryotic initiation factor; 5.8S ribosomal RNA; Ribosome biogenesis; Eukaryotic Ribosome; Cell biology; Eukaryotic Small Ribosomal Subunit; RNA; Ribosome; Initiation factor; Eukaryotic translation; Internal ribosome entry site; eIF4A; 23S ribosomal RNA; Genetics; Translation (biology); Messenger RNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007109193,0.00007861715,0.00008574656,0.00006572755,0.0002051814,0.00002662465,0.000444391,0.00008452337,0.000007837421],"category_scores_gemma":[0.0003092608,0.00005819823,0.00006543541,0.00053412,0.0005481976,0.0000297204,0.00007905677,0.00008208848,0.000003167464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001270565,"about_ca_system_score_gemma":0.00004262492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003912428,"about_ca_topic_score_gemma":7.665535e-8,"domain_scores_codex":[0.9988444,0.000006293884,0.0002466161,0.0002348608,0.0005302327,0.0001375346],"domain_scores_gemma":[0.9994501,0.00002820655,0.0002613004,0.0000116833,0.0002214106,0.00002732055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007364021,0.00001259355,0.0007708661,0.00002071823,0.00001036928,1.307433e-9,0.00006561825,0.00007639973,0.9787828,0.002925613,0.01612234,0.001205292],"study_design_scores_gemma":[0.000144876,0.00004905698,0.01290312,0.00003671158,0.000008034276,0.000004190351,0.0005306205,0.0008956136,0.9739407,0.004545027,0.006829771,0.0001123314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894333,0.0002295375,0.00001133124,0.003391353,0.00002773142,0.0001354914,0.000100835,0.00001126302,0.006659103],"genre_scores_gemma":[0.998168,0.0001423394,0.0004628936,0.000316799,0.00007269297,0.00001884821,0.000004169638,0.00000395315,0.0008103075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01213225,"threshold_uncertainty_score":0.2373255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03253286981232056,"score_gpt":0.3056146403565632,"score_spread":0.2730817705442427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}