{"id":"W4362521185","doi":"10.1073/pnas.2301081120","title":"<i>Arabidopsis</i> HOT3/eIF5B1 constrains rRNA RNAi by facilitating 18S rRNA maturation","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; University of Massachusetts Amherst; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; National Institutes of Health; National Institute of General Medical Sciences; Chinese Academy of Sciences; China Agricultural University","keywords":"18S ribosomal RNA; Biology; Ribosomal RNA; Eukaryotic initiation factor; 5.8S ribosomal RNA; Ribosome biogenesis; Eukaryotic Ribosome; Cell biology; Eukaryotic Small Ribosomal Subunit; RNA; Ribosome; Initiation factor; Eukaryotic translation; Internal ribosome entry site; eIF4A; 23S ribosomal RNA; Genetics; Translation (biology); Messenger RNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189157,0.0005742006,0.0003266278,0.0002801287,0.0004091207,0.0003866892,0.0003971955,0.0003314833,0.003395804],"category_scores_gemma":[0.0001112235,0.0003263539,0.000515472,0.0002202938,0.000328635,0.0003335022,0.0003693702,0.0009145439,0.001076759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008128296,"about_ca_system_score_gemma":0.0002722185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002328737,"about_ca_topic_score_gemma":0.004404059,"domain_scores_codex":[0.9998481,0.00000988525,0.00001234188,0.00005752819,0.00004358184,0.00002836687],"domain_scores_gemma":[0.9998842,0.00001411544,0.00003977753,0.0000210838,0.00001236755,0.00002838922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005236181,0.000005345256,0.0001146327,0.00004179902,0.000003870391,0.00002755521,0.00000933627,0.00003192655,0.9982833,0.0001371735,0.0002053884,0.001087319],"study_design_scores_gemma":[0.00001782144,0.0000461144,0.009954243,0.000009682192,0.00001906358,0.0001651952,0.00002430072,0.001274511,0.9776544,0.0001638219,0.01065403,0.00001667216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9385278,0.003141008,0.03053527,0.0008370049,0.0004073436,0.0001376211,0.01107986,0.004661187,0.01067295],"genre_scores_gemma":[0.9659565,0.0007811479,0.01428474,0.0005426842,0.00004174209,0.0001260388,0.006426271,0.001194253,0.01064657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003395804,"threshold_uncertainty_score":0.01136005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03253286981232056,"score_gpt":0.3056146403565632,"score_spread":0.2730817705442427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}