{"id":"W4362521465","doi":"10.1371/journal.pone.0269324","title":"InterMEL: An international biorepository and clinical database to uncover predictors of survival in early-stage melanoma","year":2023,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institute of General Medical Sciences; University of Texas MD Anderson Cancer Center; National Institutes of Health; Robert E. Leet and Clara Guthrie Patterson Trust; Cycle for Survival; University of Sydney; Huntsman Cancer Institute; Faculty of Medicine and Health, University of Sydney; Marie-Josée and Henry R. Kravis Center for Molecular Oncology; Memorial Sloan-Kettering Cancer Center; Australian Research Council; Char and Chuck Fowler Family Foundation; Medical Research Council; Roswell Park Alliance Foundation, Roswell Park Cancer Institute; National Cancer Institute; Melanoma Research Alliance; Cleveland Foundation; Melanoma Institute Australia; National Health and Medical Research Council; Foundation for the National Institutes of Health","keywords":"Biorepository; DNA methylation; Melanoma; Oncology; Stage (stratigraphy); Medicine; Methylation; Biology; Pathology; Bioinformatics; Cancer research; Internal medicine; Gene expression; DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000331266,0.00008086886,0.0002372762,0.0002819378,0.00001416839,0.00001314217,0.00008935024,0.00004790872,0.00007914765],"category_scores_gemma":[0.000193068,0.00007786151,0.0000337934,0.0001858257,0.00004443903,0.00008063447,0.0001646242,0.0001267168,0.00004194574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000041017,"about_ca_system_score_gemma":0.00002144497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001738322,"about_ca_topic_score_gemma":0.000252062,"domain_scores_codex":[0.9989172,0.00005283835,0.0003333091,0.0002524713,0.0003225159,0.0001216564],"domain_scores_gemma":[0.9994161,0.00006880689,0.00005479183,0.0002603165,0.00005007835,0.0001499498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004505493,0.001067525,0.9850737,0.00008491479,0.0002769264,0.0002489281,0.0002876699,0.000001838536,0.01158405,0.00007000916,0.0001448285,0.0007090007],"study_design_scores_gemma":[0.001214823,0.001033175,0.9903965,0.000205919,0.0000985734,0.00000503048,0.0002421306,0.0009374598,0.004511396,0.000004220565,0.001256262,0.00009453796],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997032,0.000004222794,0.00001884337,0.0002384523,0.0004661405,0.0003234251,0.00004868063,0.0000799601,0.001788205],"genre_scores_gemma":[0.9961305,0.0000545202,0.0002770678,0.0001092627,0.0001929219,0.00001183303,0.00005465368,0.00001579058,0.003153411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007072649,"threshold_uncertainty_score":0.31751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06312939449193494,"score_gpt":0.3125745778309881,"score_spread":0.2494451833390532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}