{"id":"W4362521465","doi":"10.1371/journal.pone.0269324","title":"InterMEL: An international biorepository and clinical database to uncover predictors of survival in early-stage melanoma","year":2023,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institute of General Medical Sciences; University of Texas MD Anderson Cancer Center; National Institutes of Health; Robert E. Leet and Clara Guthrie Patterson Trust; Cycle for Survival; University of Sydney; Huntsman Cancer Institute; Faculty of Medicine and Health, University of Sydney; Marie-Josée and Henry R. Kravis Center for Molecular Oncology; Memorial Sloan-Kettering Cancer Center; Australian Research Council; Char and Chuck Fowler Family Foundation; Medical Research Council; Roswell Park Alliance Foundation, Roswell Park Cancer Institute; National Cancer Institute; Melanoma Research Alliance; Cleveland Foundation; Melanoma Institute Australia; National Health and Medical Research Council; Foundation for the National Institutes of Health","keywords":"Biorepository; DNA methylation; Melanoma; Oncology; Stage (stratigraphy); Medicine; Methylation; Biology; Pathology; Bioinformatics; Cancer research; Internal medicine; Gene expression; DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006086331,0.0004701736,0.0007115147,0.00564792,0.000588691,0.00170297,0.00156016,0.0005315862,0.008260864],"category_scores_gemma":[0.01066113,0.0004144056,0.000407963,0.003747164,0.0003343755,0.001516358,0.002614112,0.000664904,0.003318405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001021295,"about_ca_system_score_gemma":0.002026668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002403191,"about_ca_topic_score_gemma":0.003155602,"domain_scores_codex":[0.9973598,0.0007219801,0.0004943821,0.0008349515,0.0004217156,0.0001672112],"domain_scores_gemma":[0.9884154,0.001616593,0.003600744,0.002719368,0.001480162,0.002167751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004088301,0.0006636634,0.8067374,0.001014792,0.0004115335,0.0008219198,0.0009709704,0.0007523424,0.008328985,0.002313181,0.09404422,0.07985272],"study_design_scores_gemma":[0.0006940591,0.0006590204,0.8656504,0.0004605818,0.0003177822,0.001611108,0.0007498408,0.004722121,0.004669494,0.001111648,0.1192585,0.00009538276],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.4259832,0.002688679,0.01586083,0.001765376,0.0001618405,0.004850102,0.5273581,0.003630449,0.01770142],"genre_scores_gemma":[0.4860776,0.0007542777,0.01931091,0.001266443,0.0002485333,0.005234829,0.483121,0.0004251658,0.003561184],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008260864,"threshold_uncertainty_score":0.032188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06312939449193494,"score_gpt":0.3125745778309881,"score_spread":0.2494451833390532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}