{"id":"W4362521907","doi":"10.1186/s12977-023-00618-7","title":"HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity","year":2023,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"Foreign, Commonwealth and Development Office; Government of the United Kingdom; Wellcome Trust","keywords":"Human immunodeficiency virus (HIV); Medicine; Antibody; Virology; Cell biology; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002485133,0.0002782219,0.0002452224,0.0001814854,0.0001378615,0.0003594939,0.0001231439,0.0002001327,0.001004587],"category_scores_gemma":[0.0003902817,0.0000541207,0.0002266891,0.0001619957,0.000184918,0.0001167959,0.0001371183,0.0004007037,0.0001844902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464826,"about_ca_system_score_gemma":0.0001437894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008557559,"about_ca_topic_score_gemma":0.000794236,"domain_scores_codex":[0.9998685,0.0000174317,0.00001191365,0.00003469499,0.00003880459,0.00002860461],"domain_scores_gemma":[0.9995677,0.0001219029,0.0001399793,0.00005311651,0.00004874184,0.00006852541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007570104,0.0000637332,0.06777959,0.00004757735,0.00004926146,0.0001163923,0.00003725958,0.0007103002,0.9245489,0.00009268113,0.00003966277,0.005757706],"study_design_scores_gemma":[0.00001439854,0.0006834597,0.6424146,0.00001304283,0.0001134157,0.00136227,0.00006819177,0.008736933,0.3450134,0.000102849,0.001463747,0.00001357407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998825,0.0002361477,0.0005670102,0.000007669507,0.000001681757,0.000003517772,0.00009155719,0.000006670122,0.0002607461],"genre_scores_gemma":[0.9987981,0.00007112795,0.0006272381,0.000009083597,0.00000175017,0.00000324504,0.0002352952,0.000004508644,0.0002495106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004587,"threshold_uncertainty_score":0.003360629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01482462141179564,"score_gpt":0.2575264556646387,"score_spread":0.2427018342528431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}