{"id":"W4362522244","doi":"10.1038/s41467-023-37595-6","title":"NAD+ repletion with niacin counteracts cancer cachexia","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Nutrition and Health in Aging","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Syöpäsäätiö; Fondazione Italiana per la Ricerca sul Cancro; Associazione Italiana per la Ricerca sul Cancro; Academy of Finland; Fondazione Umberto Veronesi; Trent University; Nottingham Trent University; Suomen Lääketieteen Säätiö","keywords":"NAD+ kinase; Cachexia; Niacin; Nicotinamide mononucleotide; Wasting; Nicotinamide phosphoribosyltransferase; Cancer; Mitochondrion; Nicotinamide adenine dinucleotide; Cancer research; Nicotinamide; Medicine; Endocrinology; Internal medicine; Biology; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009282459,0.0002493452,0.000316293,0.0002829565,0.0001603202,0.0002706166,0.0002867226,0.0002572543,0.00138265],"category_scores_gemma":[0.0001352235,0.00006326105,0.0001881218,0.0001988135,0.000176345,0.0001182552,0.00018365,0.0006376879,0.0002586554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001603182,"about_ca_system_score_gemma":0.0002540195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00086471,"about_ca_topic_score_gemma":0.002239357,"domain_scores_codex":[0.9999641,0.000009762545,0.000003685838,0.000005555972,0.000008365404,0.000008505765],"domain_scores_gemma":[0.9999366,0.000009942448,0.00001567443,0.000007033475,0.00001278218,0.00001803374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0149091,0.0021184,0.004026241,0.0008202526,0.0001657186,0.000301968,0.00005847025,0.0004275461,0.8813142,0.0003898772,0.002054673,0.09341375],"study_design_scores_gemma":[0.003226581,0.04265795,0.06080659,0.0002346322,0.0004578953,0.001926008,0.0003469491,0.004399567,0.8318886,0.0009656891,0.05304763,0.00004200174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726601,0.02091887,0.00138388,0.0009022022,0.0002490247,0.00009556708,0.0004335445,0.0003838062,0.00297301],"genre_scores_gemma":[0.9879711,0.005820877,0.002596133,0.0003544703,0.00005818132,0.00006220486,0.0005516077,0.00002788205,0.002557499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00138265,"threshold_uncertainty_score":0.00462544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06799025828837726,"score_gpt":0.4335867411681844,"score_spread":0.3655964828798071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}