{"id":"W4362522244","doi":"10.1038/s41467-023-37595-6","title":"NAD+ repletion with niacin counteracts cancer cachexia","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Nutrition and Health in Aging","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Syöpäsäätiö; Fondazione Italiana per la Ricerca sul Cancro; Associazione Italiana per la Ricerca sul Cancro; Academy of Finland; Fondazione Umberto Veronesi; Trent University; Nottingham Trent University; Suomen Lääketieteen Säätiö","keywords":"NAD+ kinase; Cachexia; Niacin; Nicotinamide mononucleotide; Wasting; Nicotinamide phosphoribosyltransferase; Cancer; Mitochondrion; Nicotinamide adenine dinucleotide; Cancer research; Nicotinamide; Medicine; Endocrinology; Internal medicine; Biology; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002037511,0.00007593473,0.0001331748,0.0001459324,0.000271824,0.00001564368,0.0001941281,0.0001365558,0.00008283935],"category_scores_gemma":[0.00008291082,0.00006358007,0.00002852156,0.0006321013,0.00006450098,0.00006072745,0.0000623599,0.0008998818,0.0001090149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001241324,"about_ca_system_score_gemma":0.0001532654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001057281,"about_ca_topic_score_gemma":0.001046934,"domain_scores_codex":[0.9993119,0.00004959446,0.0001550113,0.0001333703,0.00018686,0.0001632927],"domain_scores_gemma":[0.9984177,0.0001239421,0.00006566718,0.001059181,0.0002333063,0.000100209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004373126,0.0006073288,0.2216698,0.0005718564,0.0001933353,0.00004558544,0.002593326,0.00002975804,0.00843784,0.03141514,0.7240099,0.009988794],"study_design_scores_gemma":[0.0008810643,0.00004660721,0.1585179,0.0004018145,0.00004521568,0.00003763752,0.0002105027,0.0008019457,0.0002454693,0.0001079405,0.8386093,0.00009449798],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2942247,0.01732094,0.00007223962,0.6296504,0.0008036762,0.00165586,0.0001408716,0.001477274,0.05465408],"genre_scores_gemma":[0.9842419,0.003569461,0.002853872,0.006899688,0.000104346,0.0001393082,0.0003980841,0.00001986978,0.001773478],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6900172,"threshold_uncertainty_score":0.3909589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06799025828837726,"score_gpt":0.4335867411681844,"score_spread":0.3655964828798071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}