{"id":"W4362522958","doi":"10.1161/circulationaha.122.063481","title":"Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University Health Centre","funders":"National Institutes of Health; Canadian Institutes of Health Research; Austrian Science Fund; Bundesministerium für Klimaschutz, Umwelt, Energie, Mobilität, Innovation und Technologie; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Biglycan; TLR3; Cell biology; Medicine; Signal transduction; Aortic valve; Receptor; Innate immune system; Biology; Toll-like receptor; Internal medicine; Proteoglycan","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003629682,0.0004556181,0.0002558342,0.0002675412,0.0001782788,0.0003412033,0.0002936627,0.000414773,0.001633411],"category_scores_gemma":[0.0002821177,0.000125983,0.0004848054,0.0001464628,0.0003179596,0.0001570494,0.0004153239,0.0003694806,0.0003780531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002882586,"about_ca_system_score_gemma":0.0002141769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000292543,"about_ca_topic_score_gemma":0.000306677,"domain_scores_codex":[0.9998087,0.00004842714,0.00001554398,0.00003876666,0.00005014621,0.00003843901],"domain_scores_gemma":[0.9998561,0.00001989307,0.00006954656,0.00001640927,0.00001178678,0.00002621849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001192225,0.0001908119,0.02344886,0.0003112894,0.00008375398,0.00151693,0.00008469746,0.0008830173,0.9608471,0.001449535,0.0005253759,0.009466435],"study_design_scores_gemma":[0.0008183099,0.002443916,0.3917981,0.0001727527,0.0004792152,0.0148801,0.0003806627,0.02151642,0.5480747,0.003497112,0.01586826,0.00007049373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902334,0.002780892,0.003660062,0.0002839511,0.00004212029,0.00004895778,0.0003449702,0.00008804562,0.002517555],"genre_scores_gemma":[0.9967867,0.0006162058,0.001570666,0.00006942411,0.00001908617,0.00002313944,0.0002358126,0.000005109811,0.0006737864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001633411,"threshold_uncertainty_score":0.005464315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04141672122830048,"score_gpt":0.3380212869385983,"score_spread":0.2966045657102978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}