{"id":"W4362523816","doi":"10.1158/1055-9965.epi-22-0724","title":"Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis","year":2023,"lang":"en","type":"review","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"Natural Science Foundation of Zhejiang Province; Medical Research Council; Cancer Research UK; Vetenskapsrådet; Hjärt-Lungfonden; Cancerfonden; Science Fund for Distinguished Young Scholars of Zhejiang Province; National Natural Science Foundation of China","keywords":"Mendelian randomization; Colorectal cancer; Gut flora; Biology; Metabolome; Microbiome; Gammaproteobacteria; Genetics; Cancer; Bioinformatics; Immunology; Metabolomics; Gene; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04027262,0.001767828,0.002106967,0.002133865,0.0008054824,0.001310215,0.001712525,0.00136033,0.008448095],"category_scores_gemma":[0.0658514,0.0007230958,0.006067947,0.002051991,0.001216525,0.0008288243,0.001424561,0.001585505,0.0005812072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007060842,"about_ca_system_score_gemma":0.002157171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004216465,"about_ca_topic_score_gemma":0.002014061,"domain_scores_codex":[0.9462988,0.04148251,0.001517709,0.006947013,0.002601526,0.001152408],"domain_scores_gemma":[0.9447446,0.04252262,0.004999955,0.006273048,0.0009364993,0.0005233029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02383386,0.0008785405,0.6903793,0.002401901,0.0563107,0.003613865,0.001098638,0.03271292,0.01594009,0.04026855,0.003512783,0.1290489],"study_design_scores_gemma":[0.006466307,0.01289535,0.2564172,0.000851165,0.05049177,0.006186644,0.0007538215,0.5551242,0.009919056,0.08781343,0.01265995,0.0004210479],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6004119,0.002607005,0.3888963,0.001225496,0.000215793,0.001249907,0.00225261,0.0009229904,0.002217948],"genre_scores_gemma":[0.9029746,0.0005903213,0.09278648,0.0002434609,0.00005957413,0.001390529,0.0006362863,0.0001022278,0.001216582],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.04027262,"threshold_uncertainty_score":0.2129844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3628113193010852,"score_gpt":0.4442245789883231,"score_spread":0.08141325968723784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}