{"id":"W4362525148","doi":"10.1158/1538-7445.am2023-1891","title":"Abstract 1891: Breaking barriers to access intracellular targets with T-cell engagers: Discovery of diverse, developable, and ultra-specific antibodies against a MAGE-A4 pMHC","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AbCellera (Canada)","funders":"","keywords":"Antibody; Major histocompatibility complex; Computational biology; Antigen; Intracellular; MHC class I; Biology; Cell biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002746133,0.0003786966,0.0001717301,0.0001991218,0.0001513307,0.0003929662,0.0002531684,0.0004703991,0.003692639],"category_scores_gemma":[0.0002043705,0.0001102851,0.0002301768,0.0001147991,0.0001942565,0.0003109329,0.0003492326,0.0006744434,0.001050486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002930136,"about_ca_system_score_gemma":0.0002260547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002079898,"about_ca_topic_score_gemma":0.0002505042,"domain_scores_codex":[0.9998192,0.00003180233,0.000008579332,0.00003229042,0.00006396681,0.0000440937],"domain_scores_gemma":[0.9999197,0.00001500707,0.00001634523,0.000006497407,0.00002044302,0.0000219937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008336689,0.00007296236,0.000289147,0.00008143182,0.00001402942,0.00008434943,0.000023515,0.000444799,0.9845898,0.001363054,0.001240001,0.01171352],"study_design_scores_gemma":[0.00003786421,0.0005042965,0.0006819212,0.000008214004,0.00001533636,0.0001940069,0.00001611193,0.001681281,0.971659,0.0002447285,0.02494935,0.000008006619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8641852,0.007601355,0.0972757,0.001497217,0.0005979932,0.0003626459,0.000938757,0.0007088624,0.02683234],"genre_scores_gemma":[0.9337539,0.002892994,0.040482,0.0007557569,0.00009813243,0.0001804668,0.0009779792,0.0001119898,0.02074664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003692639,"threshold_uncertainty_score":0.01235306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0840318442335572,"score_gpt":0.3829362539118236,"score_spread":0.2989044096782664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}