{"id":"W4362525390","doi":"10.1158/2326-6066.c.6551066","title":"Data from Extracellular Vesicle–Packaged circATP2B4 Mediates M2 Macrophage Polarization via miR-532-3p/SREBF1 Axis to Promote Epithelial Ovarian Cancer Metastasis","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Zhejiang University; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China; McGill University","keywords":"Macrophage polarization; Ovarian cancer; Cancer research; Metastasis; Tumor microenvironment; Chemistry; Protein kinase B; PI3K/AKT/mTOR pathway; Biology; Macrophage; Cancer; Cell biology; In vitro; Signal transduction; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000510679,0.000528592,0.0006744424,0.0007688287,0.0006179116,0.0005294353,0.0002748338,0.0008293106,0.01223374],"category_scores_gemma":[0.0003159133,0.0002963024,0.001129751,0.0006609424,0.0005209511,0.0006257962,0.0003736145,0.001985764,0.003974768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005061207,"about_ca_system_score_gemma":0.000572391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001373644,"about_ca_topic_score_gemma":0.001491643,"domain_scores_codex":[0.9994212,0.00005035902,0.0000729551,0.0001326824,0.000203427,0.0001194205],"domain_scores_gemma":[0.9997085,0.00004796072,0.00004647541,0.00003461033,0.0000817301,0.00008069229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001564148,0.0001887723,0.001253069,0.0008366823,0.00005743387,0.0002882768,0.0001369206,0.0002994559,0.9837129,0.0009656502,0.003593764,0.007102886],"study_design_scores_gemma":[0.0002299422,0.0007993629,0.02299704,0.00006159512,0.0001053644,0.0009004049,0.0004256685,0.003019419,0.9392799,0.0005899475,0.03155065,0.00004070063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8560468,0.01389952,0.0344282,0.004727191,0.001849512,0.000424822,0.05586359,0.001882823,0.03087752],"genre_scores_gemma":[0.9145477,0.006003206,0.01780451,0.001873718,0.0001996049,0.001143647,0.02727236,0.0004215661,0.03073371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01223374,"threshold_uncertainty_score":0.04092592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04261356269166781,"score_gpt":0.3076386654618244,"score_spread":0.2650251027701566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}