{"id":"W4362525390","doi":"10.1158/2326-6066.c.6551066","title":"Data from Extracellular Vesicle–Packaged circATP2B4 Mediates M2 Macrophage Polarization via miR-532-3p/SREBF1 Axis to Promote Epithelial Ovarian Cancer Metastasis","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Zhejiang University; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China; McGill University","keywords":"Macrophage polarization; Ovarian cancer; Cancer research; Metastasis; Tumor microenvironment; Chemistry; Protein kinase B; PI3K/AKT/mTOR pathway; Biology; Macrophage; Cancer; Cell biology; In vitro; Signal transduction; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007565162,0.0008249019,0.0007273029,0.0002064931,0.0002044506,0.0002811978,0.002567816,0.0008700722,0.0009873863],"category_scores_gemma":[0.0008573121,0.0008621992,0.0003453268,0.0003374545,0.000135067,0.00002061643,0.00514454,0.0005597712,0.0003612126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001373111,"about_ca_system_score_gemma":0.000557863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005701022,"about_ca_topic_score_gemma":0.002824091,"domain_scores_codex":[0.9945429,0.000413881,0.0008678791,0.002716977,0.000706618,0.0007517705],"domain_scores_gemma":[0.9943171,0.00005336831,0.0004068105,0.004417189,0.000259184,0.0005463582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001386623,0.0002166092,0.001887643,0.0001678768,0.001285394,0.00008632488,0.0001058813,0.0003205356,0.9833369,0.00001283724,0.005681009,0.006760299],"study_design_scores_gemma":[0.00123397,0.0001144448,0.01601877,0.000212445,0.001171285,0.00000736831,0.0001018292,0.001788651,0.9430277,0.00114501,0.0333369,0.00184161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8342953,0.01143734,0.09452657,0.001606527,0.003099074,0.002562255,0.05200115,0.0003586075,0.000113157],"genre_scores_gemma":[0.910269,0.001014722,0.0133096,0.0005544138,0.002461049,0.0004344641,0.06916528,0.0004161833,0.002375319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08121698,"threshold_uncertainty_score":0.9999259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04261356269166781,"score_gpt":0.3076386654618244,"score_spread":0.2650251027701566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}