{"id":"W4362525948","doi":"10.1158/1538-7445.am2023-1631","title":"Abstract 1631: Combination of olverembatinib (HQP1351) with BCL-2 inhibitor lisaftoclax (APG-2575) overcomes resistance in gastrointestinal stromal tumors (GISTs)","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"GiST; Imatinib; PDGFRA; Cancer research; Tyrosine-kinase inhibitor; Myeloid leukemia; Medicine; Stromal cell; Tyrosine kinase; Stromal tumor; Imatinib mesylate; Internal medicine; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000119127,0.0003090751,0.0006846175,0.00022249,0.0001137261,0.000311325,0.0003025851,0.0003302865,0.002963264],"category_scores_gemma":[0.000106312,0.00009652784,0.0003093138,0.0002347487,0.0001460835,0.0002446379,0.0001626601,0.0006971353,0.0005411751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000232538,"about_ca_system_score_gemma":0.0003509212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006970924,"about_ca_topic_score_gemma":0.001055411,"domain_scores_codex":[0.9999115,0.00001122503,0.00001098267,0.00001704592,0.00001982208,0.00002947805],"domain_scores_gemma":[0.9999578,0.000004737791,0.000007467081,0.000004464142,0.00000513088,0.00002036602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009136118,0.003394926,0.001955039,0.0006491084,0.0001365183,0.0006964973,0.0001115574,0.0009864353,0.9065765,0.0004127802,0.00285087,0.07309364],"study_design_scores_gemma":[0.006986939,0.05540101,0.02785504,0.00005873451,0.0003274271,0.00336232,0.0001989504,0.004554345,0.8806172,0.0002198185,0.02036643,0.00005173692],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942595,0.002215046,0.0003708343,0.0001253164,0.00008882377,0.0001290115,0.0004228825,0.0001386656,0.002250016],"genre_scores_gemma":[0.9960765,0.000897523,0.0004817627,0.00009039312,0.00001493155,0.00005902615,0.0009331797,0.00001055543,0.001436075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002963264,"threshold_uncertainty_score":0.009913146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07082521652207506,"score_gpt":0.3914402362792761,"score_spread":0.320615019757201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}