{"id":"W4362534013","doi":"10.1158/1538-7445.am2023-5223","title":"Abstract 5223: Circulating lipoprotein lipids and colorectal cancer risk: A Mendelian randomization analysis from the GECCO consortium","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Mendelian randomization; Genome-wide association study; Single-nucleotide polymorphism; Colorectal cancer; Apolipoprotein B; Internal medicine; Blood lipids; Medicine; Genetics; High-density lipoprotein; Triglyceride; Apolipoprotein A1; Genetic association; Cholesterol; Lipoprotein; Oncology; Cancer; Biology; Endocrinology; Genotype; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05730965,0.002247865,0.003362467,0.002915234,0.001499249,0.00174881,0.0021591,0.002162418,0.008736142],"category_scores_gemma":[0.1117322,0.0009908071,0.006795881,0.003839305,0.001163063,0.0007200197,0.001550929,0.001478909,0.0007572034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001052296,"about_ca_system_score_gemma":0.002310082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01412762,"about_ca_topic_score_gemma":0.00624417,"domain_scores_codex":[0.8912559,0.0922394,0.002887138,0.00846621,0.004032965,0.001118367],"domain_scores_gemma":[0.9329776,0.04492178,0.006550208,0.01134029,0.003037277,0.001172821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08089095,0.0007998462,0.6425864,0.002178487,0.1137157,0.005633813,0.001131208,0.02752142,0.005350767,0.01970062,0.03257945,0.06791129],"study_design_scores_gemma":[0.06289295,0.008307615,0.4672072,0.0009858592,0.1036711,0.01013134,0.0006440817,0.2770908,0.00233475,0.03686299,0.02885323,0.001018033],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7552751,0.008037439,0.2081077,0.002779978,0.000655451,0.00512722,0.0137343,0.001652057,0.004630851],"genre_scores_gemma":[0.927141,0.0009080736,0.05719348,0.000705199,0.0002166756,0.004567819,0.007235152,0.0003771591,0.001655396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05730965,"threshold_uncertainty_score":0.303086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0332000499076254,"score_gpt":0.3509508172514392,"score_spread":0.3177507673438138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}