{"id":"W4362536143","doi":"10.1158/1538-7445.am2023-2641","title":"Abstract 2641: ZW191, a novel FRa-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Antibody-drug conjugate; Camptothecin; Antibody; Cytotoxicity; Humanized antibody; DU145; Cancer research; Conjugate; Chemistry; Cell culture; Monoclonal antibody; Molecular biology; Cancer cell; Cancer; Biology; Medicine; Immunology; In vitro; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008504032,0.0004368906,0.0001225283,0.0001825495,0.00009132586,0.0001404419,0.0002271562,0.0002592378,0.001317506],"category_scores_gemma":[0.00008095583,0.0001015833,0.000133511,0.0001359533,0.00009232846,0.0001960529,0.0001156247,0.0002501925,0.0004702624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003866603,"about_ca_system_score_gemma":0.0001950605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005049988,"about_ca_topic_score_gemma":0.0005535537,"domain_scores_codex":[0.9999373,0.000006888691,0.00000421939,0.00001495366,0.00002556152,0.00001113548],"domain_scores_gemma":[0.9999636,0.0000032168,0.00001629067,0.000001774555,0.000007765737,0.000007253575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007343147,0.00003129421,0.0001753489,0.00004647742,0.000005499566,0.0000520725,0.000006754699,0.00015007,0.9962586,0.00009718205,0.0001164152,0.002986855],"study_design_scores_gemma":[0.0000182445,0.0003595926,0.0007777864,0.000002977429,0.00001015669,0.0002509465,0.000004167154,0.0005919528,0.9949839,0.000009916705,0.002987514,0.000002729191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984885,0.00285739,0.007254834,0.0001943616,0.00004442256,0.0001247248,0.0005491662,0.0001190786,0.003971214],"genre_scores_gemma":[0.9845412,0.001565499,0.006696136,0.00006465139,0.00001572907,0.00004257474,0.001014237,0.00001720168,0.006042749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001317506,"threshold_uncertainty_score":0.004407465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.127248917654099,"score_gpt":0.4785073000761052,"score_spread":0.3512583824220062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}