{"id":"W4362540557","doi":"10.1158/1538-7445.am2023-5121","title":"Abstract 5121: TriTCE Co-stim, next generation costimulatory trispecific T cell engagers for the treatment of solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"CD28; Paratope; T cell; Cancer research; T-cell receptor; CD3; Chemistry; Cytokine; Immunology; Cell biology; Antigen; Biology; Immune system; CD8; Epitope","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116506,0.0003979173,0.0001673284,0.0002261371,0.0001215551,0.0002635854,0.0001972138,0.0003544644,0.004883704],"category_scores_gemma":[0.00005275612,0.00008398314,0.0001724549,0.0001807397,0.0001054476,0.0001893811,0.0001930248,0.0005512691,0.001778226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002521942,"about_ca_system_score_gemma":0.0001978966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003241171,"about_ca_topic_score_gemma":0.0005000998,"domain_scores_codex":[0.9999188,0.000008480159,0.000004946669,0.00001621998,0.00003087452,0.00002073604],"domain_scores_gemma":[0.9999679,0.000004543552,0.00000798415,0.000002373423,0.000007011535,0.00001016951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001340835,0.00008311118,0.0001271933,0.0001089785,0.000007893502,0.00006676247,0.00001395159,0.0003299759,0.9840525,0.0004569478,0.001132795,0.01348575],"study_design_scores_gemma":[0.00003720148,0.0007167167,0.0007833423,0.00001271745,0.00002287977,0.0004000863,0.000009903375,0.001536729,0.9747854,0.00008781024,0.02159964,0.000007535412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8921418,0.02403054,0.03765159,0.001073683,0.0004702047,0.000660995,0.002753348,0.001303038,0.0399148],"genre_scores_gemma":[0.9283659,0.008908177,0.01819645,0.0005731921,0.00008266092,0.0004048081,0.002263097,0.0001200043,0.04108565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004883704,"threshold_uncertainty_score":0.01633763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3824438603027866,"score_gpt":0.497373707859677,"score_spread":0.1149298475568904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}