{"id":"W4362540648","doi":"10.1158/1538-7445.am2023-4499","title":"Abstract 4499: The peptide-drug conjugate sudocetaxel zendusortide (TH1902) potentiates anti-tumoral activity of the anti-PD-L1 checkpoint inhibitor and induces immune cell infiltration in a B16-F10 syngeneic melanoma model","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Theratechnologies (Canada)","funders":"","keywords":"Docetaxel; Cancer research; Granzyme B; Cytotoxic T cell; Immune system; Medicine; Melanoma; Immune checkpoint; Immunotherapy; Tumor-infiltrating lymphocytes; Cancer; T cell; Immunology; Pharmacology; Internal medicine; Chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001009724,0.0003800332,0.0002461979,0.000208034,0.00009422484,0.0001559418,0.0001270218,0.000296288,0.001890327],"category_scores_gemma":[0.00003869965,0.0001036108,0.0002028502,0.0001032034,0.0001479394,0.0001745332,0.00008108555,0.0006726326,0.0004049304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001826766,"about_ca_system_score_gemma":0.0001667601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003829169,"about_ca_topic_score_gemma":0.0005066002,"domain_scores_codex":[0.9999019,0.00001630513,0.000008022801,0.00001798486,0.00002705378,0.00002872607],"domain_scores_gemma":[0.9999534,0.000005803221,0.00001221399,0.000004096439,0.000004792832,0.00001977202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003936053,0.0001230211,0.00005826239,0.00002529578,0.000003135887,0.00003225605,0.000004745975,0.00005263247,0.9983948,0.00004011819,0.00006354618,0.000808717],"study_design_scores_gemma":[0.00007283834,0.002601378,0.001164885,0.000002799354,0.00001009364,0.00014467,0.000007662965,0.0004401329,0.9944797,0.00001446954,0.001059207,0.000002275943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964714,0.0005253927,0.0008670675,0.00008691103,0.00004548736,0.00004473288,0.0004857541,0.00007079299,0.001402566],"genre_scores_gemma":[0.9939027,0.0004468125,0.001223815,0.00005052325,0.00001932491,0.00003528181,0.0007579123,0.00001566245,0.003547923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001890327,"threshold_uncertainty_score":0.006323814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03862515120491353,"score_gpt":0.3211132562112056,"score_spread":0.2824881050062921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}