{"id":"W4362540776","doi":"10.1158/1538-7445.am2023-3188","title":"Abstract 3188: Patient-derived TAC01-HER2 TAC T cells produced in Cocoon® Platform is highly functional in models of solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences","funders":"","keywords":"In vivo; CD8; In vitro; Population; Cancer research; T cell; Cytotoxic T cell; Medicine; Chimeric antigen receptor; Antigen; Molecular biology; Chemistry; Immunology; Biology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002289939,0.0005680507,0.0002919423,0.0002048248,0.0001239986,0.0004038107,0.0001807759,0.0004503233,0.004712141],"category_scores_gemma":[0.000151749,0.0001184001,0.0002520002,0.0001847682,0.0001340989,0.0002103808,0.0001818986,0.001176026,0.00156032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001804301,"about_ca_system_score_gemma":0.0001709753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003853661,"about_ca_topic_score_gemma":0.0002352396,"domain_scores_codex":[0.9997149,0.00005313335,0.00001859005,0.00007141819,0.00008085473,0.00006109665],"domain_scores_gemma":[0.9998566,0.00003306658,0.00002792588,0.00002486457,0.00002087532,0.00003671397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002144996,0.0001283348,0.0001466468,0.0000313441,0.000005559165,0.0000912157,0.00002016787,0.0001269349,0.9972351,0.00007705842,0.0002359045,0.00168718],"study_design_scores_gemma":[0.00009451473,0.001986627,0.002482971,0.00001261491,0.00004340732,0.001025729,0.00002596492,0.002976258,0.9846141,0.00006441375,0.006667752,0.000005617086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983304,0.001270596,0.008140886,0.0001276835,0.0001139038,0.0001285139,0.0009283721,0.0003432585,0.005642852],"genre_scores_gemma":[0.989734,0.000307877,0.002421895,0.00008554338,0.00003357625,0.00009187124,0.001560554,0.00006530409,0.005699331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004712141,"threshold_uncertainty_score":0.01576364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1497703571537044,"score_gpt":0.4036307582680793,"score_spread":0.2538604011143749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}