{"id":"W4362540794","doi":"10.1158/1538-7445.am2023-3951","title":"Abstract 3951: Unprecedented forward genetic screens reveal mechanisms of action, drug resistances, and hidden efficacies at amino acid resolution: combination of 5-ALA and Artesunate as a treatment option for glioblastoma multiforme","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital","funders":"","keywords":"Artemisinin; Artesunate; Computational biology; Drug discovery; Biology; Genetic screen; Cancer; Amino acid; Gene; Mechanism of action; Drug; Genetics; Bioinformatics; Pharmacology; Phenotype; In vitro; Plasmodium falciparum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002096033,0.0004730431,0.0004974645,0.0002879045,0.0001636682,0.0003211122,0.0002532126,0.000367647,0.001602341],"category_scores_gemma":[0.0002060037,0.0001219309,0.0003278392,0.0001887994,0.0002078367,0.0001613586,0.000245671,0.0005809355,0.0003689162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003996479,"about_ca_system_score_gemma":0.000272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001037388,"about_ca_topic_score_gemma":0.001569328,"domain_scores_codex":[0.9998085,0.00002828511,0.00001685927,0.00002996426,0.00008246062,0.00003400431],"domain_scores_gemma":[0.9998866,0.00002692431,0.00003105949,0.00001326176,0.00002331568,0.00001868696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000130663,0.00004919106,0.0001547184,0.00003443554,0.000009735563,0.0001033534,0.000008910838,0.0003106348,0.9954664,0.0001464409,0.0001661626,0.00341946],"study_design_scores_gemma":[0.00002846299,0.0009055648,0.001452441,0.00000750645,0.00003123232,0.000345422,0.00001498936,0.002655864,0.9918241,0.0001127922,0.002607849,0.0000137151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837899,0.002138888,0.008044522,0.000415006,0.00008153943,0.0001120281,0.001943132,0.0003300573,0.003145032],"genre_scores_gemma":[0.9898124,0.0009284735,0.006170915,0.000135008,0.00001223752,0.00004235125,0.0008145496,0.00005915322,0.002024864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602341,"threshold_uncertainty_score":0.005360425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04366231795575349,"score_gpt":0.3313684873840081,"score_spread":0.2877061694282547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}