{"id":"W4362540957","doi":"10.1158/1538-7445.am2023-1830","title":"Abstract 1830: E7386, a selective inhibitor of the interaction between β-catenin and CREB-binding protein (CBP), in combination with lenvatinib (LEN), exerts antitumor activity in preclinical tumor models with prior immune checkpoint inhibitor (ICI)-based combination treatment","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nutrasource","funders":"","keywords":"Medicine; Combination therapy; Pharmacology; Atezolizumab; Lenvatinib; Cancer; Cancer research; Nivolumab; Hepatocellular carcinoma; Internal medicine; Immunotherapy; Sorafenib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001625317,0.0006455345,0.000568396,0.0004486433,0.0002073474,0.0002585055,0.0002912173,0.000434988,0.00452225],"category_scores_gemma":[0.00007806963,0.0001474851,0.0003460388,0.0003544144,0.0003162737,0.0003035511,0.0001321424,0.001376038,0.0007996834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004155916,"about_ca_system_score_gemma":0.0008355328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00152775,"about_ca_topic_score_gemma":0.002723578,"domain_scores_codex":[0.9998044,0.00002894965,0.00001278668,0.00002745283,0.00005926927,0.00006722157],"domain_scores_gemma":[0.9999311,0.000009099071,0.00001573823,0.000005904818,0.000006053207,0.00003210947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01043963,0.007195231,0.000845507,0.000259,0.00009439227,0.0001424028,0.00003250845,0.0007904333,0.953707,0.0002093441,0.002385313,0.02389915],"study_design_scores_gemma":[0.00260561,0.04035667,0.008896292,0.00001803678,0.0001725383,0.0005088648,0.00004747593,0.001917542,0.9387523,0.00007354491,0.006632704,0.00001828772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901929,0.001919138,0.001098293,0.0002464649,0.0001269993,0.0002136673,0.00114214,0.0002262964,0.004834123],"genre_scores_gemma":[0.9903127,0.001295203,0.001415303,0.0001449846,0.00004917386,0.0001624524,0.001785046,0.0000208631,0.004814319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00452225,"threshold_uncertainty_score":0.01512849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1100394023701415,"score_gpt":0.3999675666540996,"score_spread":0.2899281642839581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}