{"id":"W4362541075","doi":"10.1158/1538-7445.am2023-2982","title":"Abstract 2982: TriTCE CPI, next generation trispecific T cell engagers with integrated checkpoint inhibition (CPI) for the treatment of solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Cancer research; Immune checkpoint; Antibody; Tumor microenvironment; T cell; Cancer immunotherapy; Antigen; Immunotherapy; Cancer; CD3; Immune system; Medicine; Chemistry; CD8; Immunology; Tumor cells; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001642376,0.0004505683,0.0001746237,0.0002561329,0.0001049166,0.0003201386,0.0002852312,0.0003963229,0.003002991],"category_scores_gemma":[0.00009491906,0.0001026135,0.0001696937,0.0002043753,0.0001478091,0.0002245266,0.0002109824,0.0007399553,0.0009125955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003322262,"about_ca_system_score_gemma":0.0002239235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003528701,"about_ca_topic_score_gemma":0.0005322975,"domain_scores_codex":[0.999856,0.00001436336,0.00000979464,0.00003454355,0.0000559925,0.00002922461],"domain_scores_gemma":[0.9999539,0.000005926634,0.00001414809,0.00000416585,0.000009914545,0.00001193216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009490977,0.00008458501,0.0001295826,0.00005965164,0.000006734936,0.00003868026,0.00001062397,0.00037991,0.9918423,0.0003329923,0.000450652,0.006569395],"study_design_scores_gemma":[0.00002839848,0.0005227455,0.0004366953,0.000004228014,0.00001094421,0.0002139038,0.000004491796,0.001830309,0.9920962,0.00005072492,0.004796626,0.000004707025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9288545,0.007235609,0.04482183,0.0004971678,0.0002018695,0.0003766965,0.001606738,0.0008008917,0.01560456],"genre_scores_gemma":[0.9683848,0.001705603,0.01694171,0.0002325516,0.00002739944,0.0001835968,0.001192213,0.00006210796,0.01126997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003002991,"threshold_uncertainty_score":0.01004606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2713833320261897,"score_gpt":0.4379267558539506,"score_spread":0.1665434238277609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}