{"id":"W4362541165","doi":"10.1158/1538-7445.am2023-1647","title":"Abstract 1647: <i>In vivo</i> efficacy and metabolism of a new synthetized dual EGFR-DNA targeting combi-molecule in a human stem cells-derived model of glioblastoma implanted intracranially in mice","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Temozolomide; U87; In vivo; Cancer research; Context (archaeology); Apoptosis; Biology; Cell culture; Stem cell; Cytotoxicity; In vitro; Glioblastoma; Cell biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009797132,0.0002576004,0.0001627432,0.0002039644,0.00005717047,0.0000908905,0.0001359234,0.000235467,0.0009087966],"category_scores_gemma":[0.00004564353,0.0000731876,0.0001597301,0.00008453635,0.0001091574,0.0001084575,0.00004446871,0.0002730606,0.0001718704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001200393,"about_ca_system_score_gemma":0.0001101825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004774869,"about_ca_topic_score_gemma":0.0003792359,"domain_scores_codex":[0.9999533,0.00000861579,0.000003583699,0.00001117822,0.00001440275,0.00000889943],"domain_scores_gemma":[0.9999648,0.000005542734,0.00001171183,0.000003441582,0.000005645779,0.000008941848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003299445,0.0001073127,0.00008371177,0.00003367899,0.000008007881,0.00002276802,0.000006768878,0.0001126781,0.9976323,0.00005533511,0.00008075404,0.001526785],"study_design_scores_gemma":[0.00004616327,0.001920175,0.0007154081,0.000002445905,0.00001698966,0.00006206534,0.00000345428,0.0005964575,0.9958334,0.000007940894,0.0007930011,0.000002497844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957776,0.0008598152,0.001461391,0.00006149369,0.00002940449,0.00006233733,0.0005123333,0.00005603968,0.00117949],"genre_scores_gemma":[0.9926499,0.0006434541,0.003008943,0.0000506628,0.00001343082,0.00008265457,0.0009852602,0.00001692353,0.002548796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009087966,"threshold_uncertainty_score":0.003040195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.051016995386862,"score_gpt":0.3570694828323065,"score_spread":0.3060524874454445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}