{"id":"W4362541661","doi":"10.1158/1538-7445.am2023-1785","title":"Abstract 1785: Multi-step engineering of gene-edited CAR T cells using RNA lipid nanoparticles","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"","keywords":"CD19; Chimeric antigen receptor; Molecular biology; Transfection; Gene expression; Biology; Cell biology; Chemistry; Flow cytometry; T cell; Gene; Immune system; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001024597,0.0002816971,0.0001513567,0.0001413349,0.00009492159,0.0002497287,0.0002035876,0.0003110399,0.001238314],"category_scores_gemma":[0.00006952595,0.00009963231,0.0001978885,0.00007785328,0.0001110901,0.0001327424,0.000194906,0.0002975046,0.0006196804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002304916,"about_ca_system_score_gemma":0.0001602329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002875658,"about_ca_topic_score_gemma":0.0003735612,"domain_scores_codex":[0.9998995,0.00001081365,0.000008736923,0.0000240626,0.00003785567,0.00001895167],"domain_scores_gemma":[0.9999609,0.000006148567,0.00001236259,0.000003792584,0.000008791974,0.000007892862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001991936,0.00001343484,0.00003070659,0.00001900581,0.00000213669,0.00003460342,0.000008884952,0.0001910761,0.998279,0.0001334069,0.0000584031,0.001209543],"study_design_scores_gemma":[0.000004924136,0.00006707783,0.00008966978,0.000001194025,0.00000300011,0.00004123707,0.00000272586,0.0009351068,0.9975001,0.00001392822,0.00133943,0.000001688604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9450105,0.0005195629,0.04767593,0.000134467,0.0001016624,0.0001656871,0.0004053838,0.0003135881,0.005673267],"genre_scores_gemma":[0.9531037,0.000282782,0.03581764,0.00006541501,0.00001273458,0.0001199429,0.0003804054,0.00008775529,0.01012953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238314,"threshold_uncertainty_score":0.004142582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1706561909875915,"score_gpt":0.4331241571840799,"score_spread":0.2624679661964884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}