{"id":"W4362541711","doi":"10.1158/1538-7445.am2023-6098","title":"Abstract 6098: Genome wide CRISPR screen reveals genetic vulnerabilities of next generation PARP1 inhibitor AZD5305","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Olaparib; Synthetic lethality; PARP1; CRISPR; PARP inhibitor; Genetic screen; Biology; Genetics; Cancer research; Gene; Mutant; Poly ADP ribose polymerase; Polymerase","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001000492,0.0004177303,0.0004628347,0.0003653076,0.000193339,0.0002640052,0.0002832199,0.0003694986,0.002919494],"category_scores_gemma":[0.0001081825,0.000132957,0.0004002513,0.0003260286,0.00015863,0.0001033177,0.0002092142,0.0005048559,0.0008482533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002618371,"about_ca_system_score_gemma":0.0002099996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128886,"about_ca_topic_score_gemma":0.001464907,"domain_scores_codex":[0.9997824,0.00001496497,0.00001869681,0.00006186926,0.00008699655,0.00003511444],"domain_scores_gemma":[0.9999264,0.00001610601,0.00002200654,0.00001055453,0.000009966773,0.00001487256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000586917,0.00002167442,0.0002428248,0.00004225913,0.000007490766,0.0001165912,0.000006832106,0.0001267702,0.9974745,0.0000574466,0.0001713085,0.001673545],"study_design_scores_gemma":[0.00001491632,0.0002351095,0.005676117,0.000006798999,0.00003663777,0.0005229,0.00002314374,0.001428082,0.9878861,0.00004526306,0.004115051,0.000009853617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9573407,0.002109719,0.01861242,0.0003107699,0.0001036549,0.000145935,0.01423794,0.00151683,0.005622142],"genre_scores_gemma":[0.9632621,0.001274619,0.01335073,0.0002754613,0.000009160797,0.0001264626,0.01241428,0.0001902813,0.009096793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002919494,"threshold_uncertainty_score":0.009766698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2514799850373327,"score_gpt":0.4536434933570905,"score_spread":0.2021635083197578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}