{"id":"W4362542562","doi":"10.1158/1538-7445.am2023-5045","title":"Abstract 5045: NTSR1-targeted alpha therapeutic [Ac-225]-FPI-2059 induces growth inhibition in a preclinical colorectal tumor model","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Patheon (Canada)","funders":"","keywords":"Biodistribution; Medicine; Pharmacokinetics; Colorectal cancer; Cancer research; In vivo; Cancer; Pharmacology; Radioligand; Therapeutic index; Internal medicine; Receptor; Drug; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000150226,0.0005197733,0.0003594793,0.0003218131,0.0001552184,0.0001850078,0.0002292182,0.000340768,0.002350861],"category_scores_gemma":[0.00006948678,0.0001401935,0.0002731117,0.0001780068,0.0002034223,0.0001745207,0.00008640978,0.0008971586,0.0006366713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000421008,"about_ca_system_score_gemma":0.0003759101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002918095,"about_ca_topic_score_gemma":0.002824212,"domain_scores_codex":[0.9998467,0.00001664686,0.00001137949,0.0000348608,0.00004686047,0.00004359766],"domain_scores_gemma":[0.9999026,0.00001456819,0.00002234141,0.000008960788,0.00001248232,0.00003899616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006573766,0.000286351,0.0001000641,0.00004832439,0.000008931044,0.00006638144,0.00001789937,0.0001669754,0.996498,0.00008761515,0.0003766497,0.001685367],"study_design_scores_gemma":[0.00006992775,0.003187561,0.001494025,0.000004939399,0.00002344752,0.0001871041,0.00001942742,0.00152298,0.9915016,0.00001676983,0.001967212,0.000005054894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898747,0.001355962,0.002629847,0.0002441226,0.0001247421,0.000100502,0.001113333,0.000330719,0.004226114],"genre_scores_gemma":[0.9822538,0.0009963922,0.003252962,0.0001059439,0.00002838576,0.0001148316,0.001953341,0.00004468501,0.01124965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002918095,"threshold_uncertainty_score":0.007864416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2649107592631865,"score_gpt":0.5139435806128593,"score_spread":0.2490328213496728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}