{"id":"W4362543029","doi":"10.1158/1538-7445.am2023-1502","title":"Abstract 1502: PRAME modulates the effect of retinoids on keratinocyte differentiation and cell cycle progression in basal cell carcinoma and cutaneous squamous cell carcinoma","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Nonmelanoma Skin Cancer Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Cancer research; Biology; Retinoid; Keratinocyte; Cell cycle; Molecular biology; Cell culture; Cell; Retinoic acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007718498,0.0002584139,0.000442198,0.0003205096,0.0002395936,0.00005154841,0.0001556815,0.0001489583,0.00004485137],"category_scores_gemma":[0.0001222207,0.0001733767,0.0000557301,0.0005223735,0.0003461007,0.00005692924,0.000254557,0.0007495372,0.00001393688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002454015,"about_ca_system_score_gemma":0.0001299976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001127991,"about_ca_topic_score_gemma":0.0001336988,"domain_scores_codex":[0.9973548,0.0003241358,0.0003381209,0.0005716842,0.0007958772,0.0006153895],"domain_scores_gemma":[0.9980358,0.001159281,0.0001151859,0.0004199871,0.0001257938,0.0001439066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001788341,0.0001118562,0.8698363,0.002429764,0.00001060447,0.0002709019,0.001883701,0.00009131225,0.1173947,0.000002802857,0.001029184,0.005150522],"study_design_scores_gemma":[0.002055194,0.001680023,0.6279576,0.000147454,0.00002369949,0.000007015557,0.0002054611,0.001099982,0.3666623,0.00002226147,0.00002758388,0.0001113665],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916845,0.004362158,4.342787e-7,0.0006337882,0.000122065,0.001573457,0.00003134782,0.00002786832,0.001564379],"genre_scores_gemma":[0.9984194,0.0004527246,0.00001432058,0.00001964208,0.0001659152,0.0003319621,0.00001896113,0.00005388719,0.0005231617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2492676,"threshold_uncertainty_score":0.7070099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02487756979064471,"score_gpt":0.342848848752373,"score_spread":0.3179712789617283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}