{"id":"W4362543748","doi":"10.1158/1538-7445.am2023-892","title":"Abstract 892: Afamitresgene autoleucel (afami-cel; formerly ADP-A2M4) demonstrates durable clinical responses by inducing broad immune engagement with anti-tumor activity","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Immune system; Tumor microenvironment; Medicine; CD8; Cancer research; FOXP3; Immunotherapy; Immunology; T cell; Internal medicine; Oncology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002216014,0.0002836125,0.000340276,0.00018845,0.0001393077,0.0003302472,0.0001773113,0.0002342524,0.005405461],"category_scores_gemma":[0.000172685,0.00007631519,0.0001787726,0.0001545882,0.0001593162,0.0001462373,0.0001155773,0.0005181276,0.001261254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002100597,"about_ca_system_score_gemma":0.0001702488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002407971,"about_ca_topic_score_gemma":0.0002359069,"domain_scores_codex":[0.9998708,0.00002410713,0.000008801475,0.00003196967,0.00003393302,0.00003030172],"domain_scores_gemma":[0.9999269,0.00001938831,0.00001596639,0.000006283307,0.000009255164,0.00002218228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.009435878,0.001256629,0.007453353,0.0001405292,0.00006563003,0.0006036511,0.00005424543,0.0003631884,0.9095845,0.0001580866,0.003228403,0.06765606],"study_design_scores_gemma":[0.002813236,0.03335276,0.08588494,0.00002236378,0.0001475995,0.007793731,0.00005716561,0.002344096,0.8447363,0.0001601206,0.02266429,0.00002325631],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899493,0.002330127,0.00197133,0.0002380333,0.0000585706,0.0001047255,0.001153249,0.0001294666,0.004065081],"genre_scores_gemma":[0.9909067,0.0004804021,0.001266853,0.0002498688,0.00007516998,0.00006418944,0.002774323,0.00002624004,0.004156278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005405461,"threshold_uncertainty_score":0.01808304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1878490284929845,"score_gpt":0.4787060654354717,"score_spread":0.2908570369424872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}