{"id":"W4362543946","doi":"10.1158/1538-7445.am2023-173","title":"Abstract 173: Genomic characterization of patient-derived pancreatic cancer organoids","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Institute of Cancer Research; University of Toronto","funders":"","keywords":"Organoid; Transcriptome; KRAS; Pancreatic cancer; CDKN2A; Biology; Cancer research; Cancer; PTEN; Irinotecan; Internal medicine; Colorectal cancer; Oncology; Medicine; Gene; Genetics; Gene expression; PI3K/AKT/mTOR pathway; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002428084,0.0001892282,0.0002588947,0.0005018842,0.000255291,0.0005023465,0.0001734649,0.0002183028,0.002413703],"category_scores_gemma":[0.0003881351,0.0001141168,0.0002842894,0.0005247839,0.0001967364,0.0001465676,0.0003272116,0.0004086999,0.0009155654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002601678,"about_ca_system_score_gemma":0.0002113347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000538571,"about_ca_topic_score_gemma":0.0005156416,"domain_scores_codex":[0.9998017,0.00002336533,0.00001867447,0.00006809276,0.00006429577,0.000023946],"domain_scores_gemma":[0.9997876,0.0000445332,0.00003187824,0.00005019974,0.00005023935,0.00003554027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003382052,0.00002768779,0.007709887,0.00006825902,0.00002096916,0.0004014033,0.0001465172,0.0003358009,0.9849899,0.00008726434,0.0002585734,0.005615475],"study_design_scores_gemma":[0.00004339722,0.000955915,0.1674271,0.00003872501,0.0001096391,0.005336204,0.0007207989,0.002999374,0.7979484,0.0003204621,0.02406827,0.0000316566],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801795,0.001133247,0.008719497,0.0001177325,0.00003816383,0.0001214167,0.007313658,0.000203188,0.002173458],"genre_scores_gemma":[0.9706929,0.000700668,0.007962972,0.0001227677,0.00001010778,0.0001989511,0.01784994,0.00009800223,0.002363741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002413703,"threshold_uncertainty_score":0.008074582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03207441286818929,"score_gpt":0.336797973624828,"score_spread":0.3047235607566387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}