{"id":"W4362544049","doi":"10.1158/1538-7445.am2023-3677","title":"Abstract 3677: DNA damage signaling activates <i>de novo</i> GTP synthesis to promote chemoradiation resistance in glioblastoma","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Purine; DNA damage; Nucleotide salvage; Cancer research; DNA repair; DNA synthesis; In vivo; Biology; In vitro; Purine metabolism; Guanine; Biochemistry; DNA; Chemistry; Enzyme; Nucleotide; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000828765,0.0002709094,0.0003571025,0.0002211828,0.0001415253,0.0003097901,0.0001645466,0.0003000174,0.002443429],"category_scores_gemma":[0.00006192512,0.0001117391,0.0002546357,0.0001576397,0.0001801887,0.000135396,0.0001441588,0.0005320152,0.0005999134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004190629,"about_ca_system_score_gemma":0.0003443712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001370689,"about_ca_topic_score_gemma":0.001936828,"domain_scores_codex":[0.9999245,0.000009716452,0.000005637895,0.00001655942,0.00002198604,0.00002165129],"domain_scores_gemma":[0.9999677,0.000003843201,0.000007627994,0.00000320944,0.000005535112,0.00001216869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002437399,0.00003533803,0.0002218052,0.00006071685,0.000006118299,0.0000593542,0.00001250583,0.00005198977,0.9966814,0.0001772079,0.0002163951,0.002233517],"study_design_scores_gemma":[0.00004519163,0.0008306291,0.008714069,0.00002327715,0.00002757684,0.0002695551,0.0000443465,0.001214238,0.9838254,0.000153797,0.004843294,0.000008722141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874577,0.004674916,0.002919498,0.0004269487,0.0001265475,0.00004999097,0.001110905,0.0003092464,0.002924257],"genre_scores_gemma":[0.9913617,0.001887665,0.001863255,0.0001689453,0.00001733964,0.00005211499,0.0008442885,0.00005081539,0.003753976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002443429,"threshold_uncertainty_score":0.008174121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03308971699942246,"score_gpt":0.3581691916124554,"score_spread":0.3250794746130329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}