{"id":"W4362546428","doi":"10.1158/2159-8290.c.6549640.v1","title":"Data from Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma","year":2023,"lang":"en","type":"preprint","venue":"","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada)","funders":"National Institutes of Health; Moffitt Cancer Center","keywords":"Cancer research; Biology; Immune system; Mantle cell lymphoma; Downregulation and upregulation; T cell; Transcriptome; Lymphoma; Immunology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001891937,0.0001944948,0.00027169,0.0006149014,0.0001456969,0.0005970772,0.0001448557,0.0002597321,0.001668021],"category_scores_gemma":[0.0004293132,0.0001241653,0.0002201048,0.0005338361,0.0001909389,0.0002722543,0.0003710547,0.0003355299,0.0003591733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002079644,"about_ca_system_score_gemma":0.0001320063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002926024,"about_ca_topic_score_gemma":0.0006318258,"domain_scores_codex":[0.9998621,0.0000127028,0.000009240708,0.00005224599,0.00004184294,0.00002177812],"domain_scores_gemma":[0.999763,0.00005568,0.00007358933,0.00003818638,0.0000376707,0.00003193694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004234072,0.00004162813,0.08642531,0.0001911278,0.000145643,0.0006752324,0.0001588875,0.001536484,0.8660128,0.000415851,0.001135722,0.04283799],"study_design_scores_gemma":[0.00002751193,0.0003579762,0.740736,0.0000639044,0.0003288116,0.00576482,0.000576892,0.008433657,0.224572,0.002576125,0.01652641,0.00003583653],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9841606,0.001458032,0.006000893,0.0002363126,0.00001480081,0.00002114132,0.006138743,0.0002058323,0.001763523],"genre_scores_gemma":[0.9910647,0.0006897673,0.002608172,0.0001608942,0.00001485944,0.00002631369,0.004787493,0.0000694695,0.0005782851],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.001668021,"threshold_uncertainty_score":0.005580008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09745959639451734,"score_gpt":0.308177417878479,"score_spread":0.2107178214839617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}