{"id":"W4362551924","doi":"10.1158/2159-8290.c.6549805","title":"Data from Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNA","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; Mount Sinai Hospital","funders":"University College London Hospitals NHS Foundation Trust; National Fusion Research Institute; Cancer Research UK; Rosetrees Trust; Making Headway Foundation; Sarcoma UK; Ira Sohn Research Conference Foundation","keywords":"CDKN2A; Malignant peripheral nerve sheath tumor; Cancer research; Genome instability; Biology; Exome sequencing; Chromosome instability; DNA methylation; Epigenetics; Comparative genomic hybridization; Copy number analysis; Neurofibromatosis; Copy-number variation; Phenotype; Genetics; Genome; DNA damage; Gene; Chromosome; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325017,0.00009840896,0.0001274199,0.0006776755,0.00009829107,0.0001959609,0.00008187231,0.0001835158,0.001999327],"category_scores_gemma":[0.0006413987,0.00005425692,0.0000971117,0.000495144,0.0001367938,0.0001226174,0.0001625483,0.0001919273,0.0003176084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001024766,"about_ca_system_score_gemma":0.00006010247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003220291,"about_ca_topic_score_gemma":0.0007010371,"domain_scores_codex":[0.9998723,0.00001504092,0.00001132774,0.00004408528,0.00003826413,0.00001889694],"domain_scores_gemma":[0.9993485,0.000160606,0.0002585269,0.00005696684,0.00005900542,0.0001164701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001686515,0.00006245817,0.8173249,0.00009162912,0.00008631797,0.0004593166,0.0001321399,0.0002209297,0.1511364,0.00008275413,0.0006392819,0.02807741],"study_design_scores_gemma":[0.000004766506,0.0001428232,0.9901523,0.000003013813,0.00001650512,0.001218733,0.00003964245,0.0001379143,0.007415373,0.00005347749,0.0008126978,0.000002668512],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952218,0.0005249908,0.0005248915,0.00004072837,0.000004301681,0.00001037726,0.002383515,0.00004719898,0.001242155],"genre_scores_gemma":[0.9965739,0.0001527316,0.0003546813,0.00002773623,0.000004550243,0.00002071583,0.002249636,0.000007829306,0.0006082699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001999327,"threshold_uncertainty_score":0.006688416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0915123704714677,"score_gpt":0.3163329081885818,"score_spread":0.2248205377171141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}