{"id":"W4362558673","doi":"10.7554/elife.87038","title":"A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Volkswagen Foundation","keywords":"Activator (genetics); Calmodulin; Biophysics; Protein subunit; Chemistry; Binding site; Small molecule; Cell biology; Biochemistry; Biology; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001518102,0.0003159555,0.000432666,0.000106011,0.0002724306,0.0003064809,0.0004193604,0.0002977318,0.00142198],"category_scores_gemma":[0.0001809529,0.0001855659,0.0002762846,0.00009235991,0.0004143192,0.0002998024,0.0003987164,0.0003901498,0.0003921406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003604127,"about_ca_system_score_gemma":0.0002702515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004392078,"about_ca_topic_score_gemma":0.0005557911,"domain_scores_codex":[0.9998928,0.00001891002,0.00000709648,0.00002741512,0.00002401097,0.00002975275],"domain_scores_gemma":[0.9999204,0.00001952333,0.00002155565,0.0000116458,0.000006059997,0.00002085252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003030164,0.0000279507,0.0005759428,0.00009380137,0.00001307224,0.0003279583,0.00007244075,0.002619118,0.9908535,0.002116137,0.0001172228,0.002879855],"study_design_scores_gemma":[0.0001798705,0.0004555533,0.006666783,0.00002841444,0.00005465901,0.001776201,0.0002034626,0.03805694,0.9427099,0.001751389,0.008068062,0.0000487809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767322,0.0007773968,0.02052906,0.0001476526,0.0000135986,0.00005743729,0.00009955651,0.0002353557,0.001407666],"genre_scores_gemma":[0.9949539,0.0001768967,0.004245929,0.00004298003,0.000003028278,0.00002417553,0.00006738681,0.000009995963,0.0004755635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142198,"threshold_uncertainty_score":0.004757047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03431933290126039,"score_gpt":0.2884908300173643,"score_spread":0.2541714971161039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}