{"id":"W4362561087","doi":"10.3390/pharmaceutics15041130","title":"Enhancing the Effectiveness of Oligonucleotide Therapeutics Using Cell-Penetrating Peptide Conjugation, Chemical Modification, and Carrier-Based Delivery Strategies","year":2023,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Muscular Dystrophy Canada; Canadian Institutes of Health Research; Alberta Innovates; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Oligonucleotide; Nucleic acid; Gene delivery; Computational biology; Genetic enhancement; Peptide; DNA; Cell-penetrating peptide; Drug delivery; RNA; Cell; Chemistry; Nanotechnology; Gene; Biology; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004025923,0.0008114054,0.0009524807,0.002179986,0.000221988,0.0008825622,0.0005899559,0.0007840833,0.002469548],"category_scores_gemma":[0.000297176,0.000283774,0.0003423661,0.001331164,0.0002844043,0.001027019,0.0005484266,0.001234096,0.001911143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005525094,"about_ca_system_score_gemma":0.0006074463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007140212,"about_ca_topic_score_gemma":0.001201519,"domain_scores_codex":[0.9998355,0.00002012066,0.00001702707,0.00002661199,0.00007818297,0.00002246263],"domain_scores_gemma":[0.9998925,0.00004463563,0.00001848338,0.000003412436,0.00003225155,0.000008724754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000488958,0.000118013,0.0001049381,0.01350119,0.00004713676,0.0003175868,0.00007330111,0.0006288799,0.02699848,0.008755964,0.0111758,0.9382297],"study_design_scores_gemma":[0.00001016234,0.0001572988,0.0003983364,0.001297052,0.00005229284,0.001403343,0.00004425786,0.0001920312,0.00968378,0.001189403,0.9855515,0.00002063138],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007950037,0.9926106,0.0008825102,0.0001812889,0.0001952067,0.00001892837,0.00002900586,0.0000231776,0.005264214],"genre_scores_gemma":[0.002561536,0.9938048,0.0008659892,0.0001398266,0.00008099833,0.00001949197,0.00004026723,0.000003899818,0.002483096],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002469548,"threshold_uncertainty_score":0.008261442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1048472393110809,"score_gpt":0.3896001477782433,"score_spread":0.2847529084671623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}