{"id":"W4362567986","doi":"10.1158/1541-7786.c.6545298.v1","title":"Data from RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy","year":2023,"lang":"en","type":"preprint","venue":"","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Augusta University","keywords":"Azoxymethane; Colorectal cancer; DNA repair; Cancer research; Cancer; Carcinogen; KRAS; DNA damage; Mouse model of colorectal and intestinal cancer; Aberrant crypt foci; RAD51; Medicine; Biology; Internal medicine; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002165637,0.0004086013,0.0006758232,0.0007096596,0.0002389054,0.0003512532,0.0003333353,0.0005951503,0.0106977],"category_scores_gemma":[0.0001662639,0.0002137412,0.0006503236,0.0003894349,0.0003386611,0.0003666757,0.0002024394,0.00185437,0.002081366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003939444,"about_ca_system_score_gemma":0.0003555891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004421,"about_ca_topic_score_gemma":0.001578853,"domain_scores_codex":[0.9996883,0.00003651499,0.00004916028,0.00005890475,0.00009534206,0.00007179254],"domain_scores_gemma":[0.9997339,0.00003720916,0.00004858272,0.00004514687,0.00003551952,0.00009956917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00204762,0.0006285846,0.0008628116,0.0003822158,0.00005855291,0.0002076544,0.00007737531,0.0003072093,0.9759746,0.0005046558,0.003607927,0.01534067],"study_design_scores_gemma":[0.0002327471,0.002948864,0.01714484,0.00004025069,0.00007963079,0.0005816119,0.0001229316,0.001410738,0.9539326,0.000225789,0.02325745,0.00002251374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9544712,0.008653421,0.004347658,0.002272565,0.0006635181,0.0002682508,0.013386,0.001306843,0.01463047],"genre_scores_gemma":[0.957029,0.003731327,0.002711231,0.0008684482,0.00006802121,0.0004571947,0.009759868,0.0001261102,0.02524894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0106977,"threshold_uncertainty_score":0.03578734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03338968182479884,"score_gpt":0.2882028804613286,"score_spread":0.2548131986365297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}