{"id":"W4362574927","doi":"10.1016/j.ajt.2023.03.022","title":"TNX-1500, a crystallizable fragment–modified anti-CD154 antibody, prolongs nonhuman primate renal allograft survival","year":2023,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Servier","keywords":"CD154; Monoclonal antibody; Medicine; Antibody; In vivo; Kidney; Immunology; Blockade; In vitro; Kidney transplantation; Receptor; Platelet activation; Platelet; CD40; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094175,0.0002969588,0.0002995549,0.0001702971,0.0001543891,0.000278763,0.000238825,0.000295125,0.001162243],"category_scores_gemma":[0.0001274023,0.00007257718,0.0001702334,0.00009067269,0.0002065046,0.0002752479,0.00009389011,0.0006653126,0.0002404477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002302831,"about_ca_system_score_gemma":0.0002612795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005658732,"about_ca_topic_score_gemma":0.001048227,"domain_scores_codex":[0.9999237,0.00001356364,0.000004889562,0.00001559203,0.00001643978,0.00002573714],"domain_scores_gemma":[0.9999046,0.00001459558,0.00002652234,0.00001156735,0.00001021967,0.0000323731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001476716,0.0002357644,0.0002869369,0.00006555626,0.00001684194,0.00009003711,0.00003283738,0.0001771994,0.9884609,0.0002191604,0.0002243931,0.008713699],"study_design_scores_gemma":[0.0001143409,0.007773042,0.005959556,0.00002809464,0.00007963319,0.0008027555,0.00004984938,0.001529948,0.977647,0.0001910798,0.005814635,0.00001017702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993654,0.003358708,0.001395405,0.00008560253,0.00006522497,0.00001964155,0.00008777507,0.00007710869,0.001256538],"genre_scores_gemma":[0.9952049,0.001343204,0.0008623213,0.00005456445,0.00002056316,0.00001641693,0.0001986138,0.0000198598,0.002279504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001162243,"threshold_uncertainty_score":0.003888071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01558028144772396,"score_gpt":0.295248804292824,"score_spread":0.2796685228451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}