{"id":"W4362575914","doi":"10.1016/j.jaci.2023.03.024","title":"In vitro/ex vivo assays for severe cutaneous drug reactions","year":2023,"lang":"en","type":"editorial","venue":"Journal of Allergy and Clinical Immunology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Fondation de l'Hôpital Général de Montréal; University of Melbourne; McGill University Health Centre; National Health and Medical Research Council; Austin Medical Research Foundation","keywords":"Acute generalized exanthematous pustulosis; Toxic epidermal necrolysis; Ex vivo; Medicine; Scars; In vivo; Dermatology; Context (archaeology); Drug; Pathology; Immunology; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006103312,0.004158297,0.003321707,0.002766559,0.00120507,0.003519088,0.002786247,0.01131092,0.005259286],"category_scores_gemma":[0.009623257,0.001072537,0.002127409,0.0006849483,0.00151568,0.0022739,0.0007536117,0.01414677,0.0058587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001514373,"about_ca_system_score_gemma":0.0009191302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004713484,"about_ca_topic_score_gemma":0.001750041,"domain_scores_codex":[0.9947975,0.001310277,0.0008067323,0.0003458696,0.002510583,0.0002290192],"domain_scores_gemma":[0.9843018,0.006831245,0.001022615,0.0005726842,0.005845113,0.001426529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002862224,0.0001102655,0.0001678086,0.0007840819,0.00007606718,0.001057244,0.00001860426,0.00005909858,0.002105037,0.0003702422,0.9631975,0.03176793],"study_design_scores_gemma":[0.000388143,0.000433654,0.002106303,0.0005007599,0.0002956383,0.002809171,0.00006205042,0.0006190452,0.003538578,0.000935189,0.9882646,0.00004683829],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0003712145,0.01385577,0.0006784284,0.02313256,0.9585317,0.0000668604,0.0000753866,0.0001287089,0.003159384],"genre_scores_gemma":[0.002563139,0.009655233,0.000679869,0.02298395,0.94954,0.00004909456,0.000073415,0.00004746511,0.01440778],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.01131092,"threshold_uncertainty_score":0.03227776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02519618261245495,"score_gpt":0.3565707184485312,"score_spread":0.3313745358360762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}