{"id":"W4362579425","doi":"10.1101/2023.03.31.23287839","title":"Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Impact; Hamilton Health Sciences; University of Toronto; McMaster University; Population Health Research Institute","funders":"National Human Genome Research Institute; Manchester Biomedical Research Centre; National Institute for Health and Care Research; Medical Research Council; American Diabetes Association; American Heart Association; National Institute of Diabetes and Digestive and Kidney Diseases; Versus Arthritis","keywords":"Genome-wide association study; Type 2 diabetes; Biology; Genetic association; Genetics; Expression quantitative trait loci; Genetic architecture; Genetic genealogy; Epigenomics; Disease; Genetic heterogeneity; Mendelian randomization; Evolutionary biology; Bioinformatics; Quantitative trait locus; Diabetes mellitus; Single-nucleotide polymorphism; Medicine; Internal medicine; Phenotype; Genotype; Gene; Endocrinology; Genetic variants; DNA methylation; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009819841,0.0004619598,0.0007343773,0.0008702567,0.0007164611,0.001021676,0.0003980032,0.0006471268,0.002543704],"category_scores_gemma":[0.002429211,0.0002960835,0.001043273,0.001956092,0.0004044863,0.0002565978,0.001433315,0.0006032806,0.0003023885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001579568,"about_ca_system_score_gemma":0.0001881202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00537251,"about_ca_topic_score_gemma":0.006277144,"domain_scores_codex":[0.9989151,0.000320715,0.00006487912,0.0005014429,0.0001040912,0.00009381395],"domain_scores_gemma":[0.999029,0.0002967744,0.0002112858,0.0002994214,0.00005560571,0.0001078882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008325523,0.00005372596,0.9535785,0.00007069166,0.002384762,0.0003550694,0.0005896365,0.001296207,0.02313818,0.0004820143,0.001007046,0.01621163],"study_design_scores_gemma":[0.00002709925,0.00007090047,0.9953589,0.000009677381,0.0004574499,0.0003498392,0.000117712,0.001294965,0.0006538351,0.000463127,0.001184392,0.00001202889],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947268,0.0002873488,0.002975965,0.00006336606,0.000009754081,0.00001165462,0.001438231,0.00005311886,0.0004337277],"genre_scores_gemma":[0.9951928,0.0001476806,0.002166013,0.00006908305,0.00001197123,0.00002472224,0.002032162,0.00002676867,0.0003289014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00537251,"threshold_uncertainty_score":0.01068252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08101448952639158,"score_gpt":0.3228501177803538,"score_spread":0.2418356282539623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}