{"id":"W4362592213","doi":"10.1158/1538-7445.am2023-2942","title":"Abstract 2942: ZW171, a T cell-engaging, bispecific antibody for the treatment of mesothelin-expressing solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Mesothelin; Cancer research; Bispecific antibody; Paratope; Antibody; T cell; CD3; Cytotoxicity; Chemistry; Antigen; Medicine; Immunology; Immune system; Monoclonal antibody; In vitro; Biochemistry; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001332848,0.0005719727,0.000210663,0.0002640059,0.0001132239,0.0002001585,0.0002893823,0.0004309067,0.002828373],"category_scores_gemma":[0.00007034759,0.0001020835,0.0002264324,0.0001550829,0.000122548,0.0001790058,0.00017282,0.0007034701,0.001089848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002078423,"about_ca_system_score_gemma":0.0003462397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003526819,"about_ca_topic_score_gemma":0.0003218944,"domain_scores_codex":[0.9999412,0.000009150758,0.000004094147,0.00001154167,0.00001782702,0.00001613454],"domain_scores_gemma":[0.9999729,0.00000308003,0.000005818719,0.000001605818,0.000005991036,0.00001057384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004854484,0.0002103378,0.0001656144,0.0001817893,0.00001746737,0.0001796531,0.00001381054,0.0003112834,0.9819865,0.000371157,0.00130166,0.01477527],"study_design_scores_gemma":[0.0005549945,0.002748661,0.001707804,0.00002436275,0.00006854568,0.001529942,0.00001685724,0.002232346,0.9652048,0.0001797894,0.02571914,0.00001277109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9447217,0.01943725,0.01654669,0.0009566692,0.0005256044,0.0005546591,0.00131642,0.0004938639,0.01544714],"genre_scores_gemma":[0.9687743,0.007203253,0.007686247,0.0005481368,0.0001036127,0.0003066632,0.002094766,0.00006751405,0.01321551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002828373,"threshold_uncertainty_score":0.00946182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1809970216461742,"score_gpt":0.4940730700699903,"score_spread":0.3130760484238161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}