{"id":"W4362592768","doi":"10.1158/1538-7445.am2023-3281","title":"Abstract 3281: GEN1042 (DuoBody-CD40x4-1BB)®in combination with PD-1 blockade reverses T-cell exhaustion <i>in vitro</i>","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Optech (Canada)","funders":"","keywords":"CD28; T cell; CD40; Priming (agriculture); Immune system; IL-2 receptor; Mixed lymphocyte reaction; Cytokine; Immunology; Biology; Chemistry; Cancer research; In vitro; Cytotoxic T cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001903826,0.0003859648,0.0005432542,0.0002888961,0.0001483089,0.0004510842,0.0001998177,0.0002724082,0.004305267],"category_scores_gemma":[0.0001000177,0.0001432252,0.0003220513,0.0003075683,0.0001454959,0.0001253007,0.0001473174,0.0006582484,0.001079571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003252231,"about_ca_system_score_gemma":0.0004310189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007826377,"about_ca_topic_score_gemma":0.001359159,"domain_scores_codex":[0.9998554,0.00001745473,0.000009267254,0.0000400043,0.00004663032,0.0000311959],"domain_scores_gemma":[0.9999298,0.00001219667,0.00002450236,0.000006648195,0.00001210218,0.00001464815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001921898,0.000161804,0.001289493,0.0002389085,0.0000539759,0.00005496107,0.00001377794,0.000712271,0.9818432,0.00005979125,0.002832399,0.01081756],"study_design_scores_gemma":[0.0003145903,0.003816146,0.0179237,0.00002974851,0.0001676604,0.0003033523,0.00004676274,0.003569066,0.9541548,0.000114595,0.01953708,0.00002240729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708717,0.003724911,0.002835057,0.0003001558,0.0002138572,0.0001220415,0.01734744,0.0006605699,0.003924157],"genre_scores_gemma":[0.9408642,0.002428249,0.004102527,0.000757559,0.00006263616,0.0003070355,0.04206555,0.0002001398,0.009212083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004305267,"threshold_uncertainty_score":0.01440257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06643323065617299,"score_gpt":0.3863915877639397,"score_spread":0.3199583571077667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}