{"id":"W4362592856","doi":"10.1158/1538-7445.am2023-4493","title":"Abstract 4493: Sudocetaxel Zendusortide (TH1902), a peptide-drug conjugate for the treatment of sortilin-positive (SORT1+) TNBC and Her2-positive breast cancers","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Theratechnologies (Canada)","funders":"","keywords":"Internalization; Breast cancer; Cancer research; Triple-negative breast cancer; Cancer; Endosome; Cancer cell; Biology; Receptor; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009012427,0.0002819819,0.0001827191,0.0001691752,0.0001081812,0.0001724796,0.0001488139,0.000296308,0.003082034],"category_scores_gemma":[0.00004737132,0.0001007221,0.000133649,0.000131112,0.00008184476,0.000132112,0.0001409024,0.0003531713,0.0008717032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00021678,"about_ca_system_score_gemma":0.000184821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003517832,"about_ca_topic_score_gemma":0.0003847701,"domain_scores_codex":[0.9999508,0.000007505826,0.000004522745,0.00001081142,0.00001569459,0.00001066155],"domain_scores_gemma":[0.999983,0.000002424244,0.000003862996,0.000001252072,0.000002791909,0.000006831537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003505577,0.0000566936,0.0001400341,0.00008327961,0.000007552358,0.00008738889,0.000009243932,0.000104334,0.9927272,0.00008846724,0.0003173428,0.006028008],"study_design_scores_gemma":[0.00008910528,0.0008176662,0.001470805,0.000005680263,0.00001542844,0.0006501341,0.000006573862,0.0006551601,0.9901169,0.00001950353,0.006147833,0.000005165437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820678,0.006578759,0.003859279,0.0002567151,0.0001582282,0.000125277,0.0007956436,0.0001859809,0.005972283],"genre_scores_gemma":[0.9858668,0.002259612,0.003861306,0.0001175851,0.00003256591,0.00006106866,0.001232527,0.00003231877,0.006536094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003082034,"threshold_uncertainty_score":0.01031041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04651636214469661,"score_gpt":0.3949825495928154,"score_spread":0.3484661874481187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}