{"id":"W4362592856","doi":"10.1158/1538-7445.am2023-4493","title":"Abstract 4493: Sudocetaxel Zendusortide (TH1902), a peptide-drug conjugate for the treatment of sortilin-positive (SORT1+) TNBC and Her2-positive breast cancers","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Theratechnologies (Canada)","funders":"","keywords":"Internalization; Breast cancer; Cancer research; Triple-negative breast cancer; Cancer; Endosome; Cancer cell; Biology; Receptor; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004239263,0.000205254,0.0002317932,0.0001174067,0.000349488,0.00005473984,0.0002316453,0.0001038477,0.00008912131],"category_scores_gemma":[0.00009207175,0.0001572359,0.000158002,0.0002829069,0.0004581672,0.00001259278,0.0001029533,0.0001988274,0.0000178239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002507067,"about_ca_system_score_gemma":0.0005429669,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007654114,"about_ca_topic_score_gemma":0.004579986,"domain_scores_codex":[0.9982077,0.0001074381,0.000282295,0.0005294674,0.0003011484,0.0005719528],"domain_scores_gemma":[0.9984655,0.0003180664,0.0001133046,0.0004145596,0.000548733,0.0001398092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001585347,0.0001780345,0.002835013,0.0000975267,0.0008792389,0.00003121679,0.0009989291,0.0003281185,0.956531,0.00009368912,0.01124104,0.02520086],"study_design_scores_gemma":[0.001226288,0.0007943777,0.054626,0.0001335442,0.00006660471,0.00002099668,0.001428876,0.0001406219,0.9223713,0.0001108483,0.01884928,0.0002312392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914199,0.002729509,0.00007160606,0.001904512,0.0001784219,0.001608103,0.001650843,0.00001911107,0.0004180527],"genre_scores_gemma":[0.9863689,0.007682077,0.00004597343,0.00005454037,0.0003384247,0.001754217,0.000171484,0.00004972184,0.003534673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05179099,"threshold_uncertainty_score":0.998954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04651636214469661,"score_gpt":0.3949825495928154,"score_spread":0.3484661874481187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}