{"id":"W4362593083","doi":"10.1158/1538-7445.am2023-3998","title":"Abstract 3998: Metronomic gemcitabine plus neratinib effectively inhibits the growth of human Her-2 positive breast cancer cells intracranially implanted into immunodeficient mice","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Neratinib; Gemcitabine; Lapatinib; Medicine; Breast cancer; Oncology; Cancer; Metastatic breast cancer; Internal medicine; In vivo; Cancer research; Trastuzumab; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001501637,0.0003790346,0.0006996653,0.0005461696,0.0005495812,0.0000671847,0.0005367546,0.0001531941,0.0004379886],"category_scores_gemma":[0.00007370851,0.0002803471,0.0001865388,0.001777628,0.0008081701,0.0002123308,0.0003026731,0.001173063,0.0001040958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001989674,"about_ca_system_score_gemma":0.001143245,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01672686,"about_ca_topic_score_gemma":0.000994032,"domain_scores_codex":[0.9962775,0.0003071344,0.0005991659,0.0007165857,0.001057856,0.001041788],"domain_scores_gemma":[0.9971196,0.0005994865,0.0002299856,0.0005577669,0.00128288,0.0002102936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002759465,0.0001415787,0.0009657821,0.0004137513,0.0004329045,0.00004524506,0.003376071,0.0003877607,0.9753824,0.0001937401,0.0005230874,0.01537819],"study_design_scores_gemma":[0.005019782,0.0005181724,0.2833731,0.001173854,0.0001028441,0.00006341914,0.00176302,0.0001829498,0.7069477,0.0002629058,0.0002142138,0.000377994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909363,0.002584297,0.00004756337,0.003303007,0.0003358809,0.001710095,0.0006601727,0.0001177381,0.0003048772],"genre_scores_gemma":[0.9974083,0.0005262336,0.00005711129,0.0001619585,0.0005407911,0.0007461322,0.00007188226,0.0001155248,0.0003720335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2824073,"threshold_uncertainty_score":0.9999649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03244288141759056,"score_gpt":0.3800918746567812,"score_spread":0.3476489932391907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}