{"id":"W4362594015","doi":"10.1158/1538-7445.am2023-2935","title":"Abstract 2935: ZW270, a conditionally masked IL-12 cytokine fusion protein displaying potent anti-tumor activity absent systemic toxicity","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Potency; Cytokine; Pharmacology; Cytotoxic T cell; Fusion protein; Toxicity; Recombinant DNA; Chemistry; Immunology; Cancer research; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081158,0.0003966896,0.0001802137,0.0001156917,0.00008448631,0.0001744796,0.0002199676,0.00029301,0.002019582],"category_scores_gemma":[0.0000719796,0.00008220338,0.0001623946,0.0001069668,0.0002134312,0.0001401952,0.0001110518,0.0005376278,0.0007032579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002780904,"about_ca_system_score_gemma":0.0002510745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008763244,"about_ca_topic_score_gemma":0.0007536896,"domain_scores_codex":[0.9998957,0.00001244698,0.000008301192,0.00002126506,0.00003877912,0.00002349434],"domain_scores_gemma":[0.9999515,0.000007292766,0.0000146802,0.000005028064,0.000009054054,0.00001248555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001145313,0.0000264908,0.00004048648,0.00002016664,0.000002297972,0.00003123884,0.000004691587,0.0001282063,0.9986778,0.00007062517,0.00008004345,0.0008034037],"study_design_scores_gemma":[0.00001743137,0.0003042079,0.0003310893,0.000002099802,0.000005857969,0.0001174359,0.000005356226,0.0004091738,0.9972022,0.00001276829,0.001590553,0.000001949715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866512,0.001006366,0.007385158,0.0001459891,0.00004312929,0.0001015593,0.001488768,0.0001865199,0.00299121],"genre_scores_gemma":[0.986726,0.0005908911,0.004409809,0.00007246341,0.00001009454,0.00006688783,0.001884743,0.00004304097,0.006195941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002019582,"threshold_uncertainty_score":0.006756186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09976051613072782,"score_gpt":0.4081692322461326,"score_spread":0.3084087161154048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}